Epileptogenesis in Tuberous Sclerosis

  1. Zhang B, McDaniel S, Rensing NR. Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. PLoS One 2013;e57445.
  2. Zeng LH, Rensing NR, Zhang B, Gutmann DH, Gambello MJ, Wong M. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex. Hum Mol Genet 2011; 20:445-454.
  3. Zeng LH, Bero AW, Zhang B, Holtzman DH, Wong M. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiol Dis 2010; 37:764-771.
  4. Xu L, Zeng LH, Wong M. Impaired astrocyte gap junction coupling and potassium buffering in a mouse model of Tuberous Sclerosis Complex. Neurobiol Dis 2009; 34:291-299.
  5. Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 2008; 63:444-453.
  6. Wong M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development. Epilepsia 2008, 49:8-21.
  7. Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M. Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiol Dis 2007; 28:184-196.
  8. Wong M. The utility of tuber-less models of tuberous sclerosis. Epilepsia 2007, 48:1629-1630.
  9. Erbayat-Altay E, Zeng LH, Xu L, Gutmann D, Wong M. The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. Epilepsia 2007; 48:1470-1476.
  10. Jansen LA, Uhlmann EJ, Gutmann DH, Wong M. Epileptogenesis and reduced inward rectifier potassium current in Tuberous Sclerosis Complex-1 deficient astrocytes. Epilepsia 2005; 46:1871-1880.
  11. Wong M, Ess KE, Uhlmann EJ, Jansen LA, Li W, Crino PB, Mennerick S, Yamada KA, Gutmann DH. Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis complex. Ann Neurol 2003; 54:251-256.
  12. Uhlmann EJ, Wong M, Baldwin RL, Bajenaru ML, Onda H, Kwiatkowski DJ, Yamada KA, Gutmann DH. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol 2002; 52:285-296.

Seizure-Induced Brain Injury

  1. Guo DG, Arnspiger S, Rensing NR, Wong M. Brief seizures cause dendritic injury. Neurobiol Dis 2012; 45:348-355.
  2. Zeng LH, Xu, L, Rensing NR, Sinatra PM, Rothman SM, Wong M. Kainate seizures cause acute dendritic spine loss and actin depolymerization in vivo. J Neurosci 2007; 27:11604-11613.
  3. Ouyang Y, Yang XF, Hu XY, Erbayat-Altay E, Zeng LH, Lee JL, Wong M. Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes. Brain Res 2007; 1143:238-246.
  4. Rensing NR, Ouyang Y, Yang XF, Yamada KA, Rothman SM, Wong M. In vivo imaging of dendritic spines during electrographic seizures. Ann Neurol 2005; 58:888-898.
  5. Ouyang Y, Wong M, Capani F, Rensing N, Lee CS, Liu Q, Martone ME, Wu J, Ellisman MH, Yamada K, Choi DW. A transient decrease in F-actin may be necessary for translocation of proteins into dendritic spines. Eur J Neurosci 2005; 22:2995-3005.
  6. Wong M. Modulation of dendritic spines in epilepsy: cellular mechanisms and functional implications. Epilepsy & Behav 2005; 7:569-577.

Other Epilepsy Models

  1. Guo DG, Zeng LH, Brody DL, Wong M. Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury. PLoS One 2013.
  2. Zhang B, Wong M. Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat. Epilepsia 2012; 53:506-511.
  3. McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia 2011; 52:e7-e11
  4. Zeng LH, Rensing NR, Wong M. The mammalian target of rapamycin (mTOR) signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 2009; 29:6964-6972.
  5. Shakkottai VG, Xiao M, Xu L, Wong M, Nerbonne JM, Ornitz DM, Yamada KA. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiol Dis 2009; 33:81-88.
  6. Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA. Leptin inhibits 4-aminopyridine- and penetyelentetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Investigation 2008; 118:272-280.
  7. Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neurosci Lett 2008; 433;82-86.
  8. Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD. Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis. Neurobiol Dis 2007; 25:150-162.
  9. Griffey MA, Wozniak D, Wong M, Bible E, Johnson K, Rothman SM, Wentz A, Cooper JD, Sands M. CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosis. Molec Therap 2006; 13:538-547.
  10. Wong M. Advances in the pathophysiology of developmental epilepsies. Seminars in Ped Neurol. 2005;12:72-87.
  11. Wong M, Wozniak M, Yamada KA. An animal model of generalized non-convulsive status epilepticus: immediate characteristics and long-term effects. Exp Neurol 2003; 183:87-99.
  12. Wang Q, Bardgett ME, Wong M, Wozniak DF, Lou J, McNeil BD, Chen C, Nardi A, Reid DC, Yamada KA, Ornitz DM. Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron 2002; 35:25-38.
  13. Wong M, Yamada KA. Developmental characteristics of epileptiform activity in immature rat neocortex: a comparison of four in vitro seizure models. Dev Brain Res 2001; 128:113-120.
  14. Hill MW, Wong M, Amarakone A, Rothman SM. Rapid cooling aborts seizure-like activity in rodent hippocampal-entorhinal slices. Epilepsia 2000; 41:1241-1248.
  15. Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 2000; 54:325-331.
  16. Wong M, Yamada KA. Cyclosporine induces epileptiform activity in an in vitro seizure model. Epilepsia 2000; 41:271-276.

Human CSF Studies

  1. Gurnett CA, Landt M, Wong M. Analysis of cerebrospinal fluid glial fibrillary acidic protein after seizures in children. Epilepsia 2003; 44:1455-1458.
  2. Wong M, Ess K, Landt M. Cerebrospinal fluid neuron-specific enolase following seizures in children: role of etiology. J Child Neurol 2002; 17:261-264.
  3. Wong M, Schlaggar BL, Landt M. Postictal cerebrospinal fluid abnormalities in children. J Pediatr 2001; 138:373-377.
  4. Landt M, Parvin CA, Wong M. Leptin concentrations in cerebrospinal fluid from children. Clin Chem 2000, 46:854-858.
  5. Wong M, Schlaggar BL, Buller RS, Storch GA, Landt M. Cerebrospinal fluid protein in pediatric patients: defining clinically-relevant reference values. Arch Pediatr Adolescent Med 2000; 154:827-831.