About the Lab

The primary goal of my research laboratory is to understanWongd biological mechanisms in the brain underlying epilepsy, with the ultimate purpose of developing new therapies for epilepsy patients. We have focused on investigating cellular and molecular mechanisms of epileptogenesis and seizure-induced brain injury in animal models of epilepsy. Both pharmacological and genetic models of epilepsy are studied on the behavioral, circuit, cellular, and molecular level. A wide variety of experimental approaches are utilized, including electrophysiological (from patch-clamping in culture cells and slice preparations to in vivo video-EEG monitoring), histological (conventional and fluorescent assays), molecular biological (Western blotting, polymerase chain reaction), and modern cellular imaging (confocal and two-photon microscopy of in vivo, live slice, and fixed tissue preparations) techniques.
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About Dr. Wong

Dr. Wong is a board-certified pediatric neurologist, specializing in clinical pediatric epilepsy and basic epilepsy research. As part of the Pediatric Epilepsy Center, Dr. Wong’s clinical responsibilities include outpatient epilepsy clinic and inpatient neurology attending, as well as interpretation of EEG and long-term video-EEG monitoring studies at St. Louis Children’s Hospital. He also serves as Director of the Washington University Tuberous Sclerosis Clinic, one of several recognized specialty clinics devoted to patients with Tuberous Sclerosis in the United States. Dr. Wong is board certified by the American Board of Psychiatry and Neurology with Special Qualification in Child Neurology, the American Board of Psychiatry and Neurology with Special Qualification in Clinical Neurophysiology, and the American Board of Clinical Neurophysiology (Epilepsy Monitoring Track). He is named in the Best Doctors in America for Child Neurology and has been awarded a number of federal and private research grants to study epilepsy. He received the Dreifuss-Penry Epilepsy Award from the American Academy of Neurology in 2009.
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