The development of the mammalian brain is a highly regulated process involving both cell-autonomous and non-cell-autonomous determinants that control cell fate, growth, migration, and death decisions. The genes that govern these critical decisions are often mutated in human neurogenetic conditions. One of the most common of these disorders is neurofibromatosis type 1 (NF1).
Using NF1 as a model genetic system to understand growth and differentiation in the normal brain, the Gutmann laboratory aims to characterize the genomic, genetic, cellular, and molecular factors that contribute to the development of nervous system tumors (gliomas and neurofibromas) and cognitive problems (learning and attention deficits). Defining these contributing factors represents the first step toward establishing new treatments for children and adults with NF1. Moreover, NF1 provides unique opportunities to unravel the complexities of related medical problems in the general population, including adult and childhood brain tumors, nerve tumors, sarcoma, and autism.
Areas of Investigation:
- Growth regulation in the nervous system
- Stem cells in brain development and cancer
- Tumor microenvironment and immunology
- Genetics and genomics of cancer
- Genetically-engineered mouse models of cancer
- Sexually-dimorphic effects in cancer
- Neuronal influences on cancer development and progression
- Precision medicine and oncology
Visit the Gutmann Research Laboratory website to learn more.
Contact the Gutmann Research Laboratory
Kristi Bullock, Administrative Assistant to David H. Gutmann
2208 McMillan Building
660 S. Euclid Avenue, Campus Box 8111
St. Louis, MO 63110