Diringer Laboratory

Michael N. Diringer, MD

All NNICU physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a Positron Emission Tomography (PET) scanner located on site. The PET scanner is a tool that can measure brain blood flow and metabolism which are key factors in understanding the impact of our treatments. The PET room is equipped as any other ICU room and contains all the necessary equipment needed to care for a critically ill patient. The facility is funded by grants from the National Institutes of Health.

The NNICU also supports a wide range of other clinical investigations which complement our PET studies.
Current areas of active research include:
• Time course of cerebral edema formation around intracerebral hemorrhage
• Glucose metabolism following intracerebral hemorrhage
• Effect of mannitol on sodium homeostasis and osmolality
• Impact of mannitol and hypertonic saline on CBF and brain volume
• Systemic inflammatory response in subarachnoid hemorrhage
• APO-e in subarachnoid hemorrhage
• Hemodynamic augmentation in subarachnoid hemorrhage
• Impact of stains on autoregulation in acute SAH
• Use of prothrombin complex in the reversal of coumadin induced coagulopathy

Neurologic Intensive Care