Dr Clifford is the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology at Washington University in St. Louis. A primary career goal has been to improve therapeutics for neurological disorders, with a particular focus on neurological complications of HIV. Since 1993, he led the Neurologic AIDS Research Consortium, an NIH funded national research group designed to develop improved therapy for neuroAIDS complications. He has been the Principal Investigator of the AIDS Clinical Trials Unit at Washington University which is the premier international NIH funded AIDS therapeutic network, as well as being active investigator in the CHARTER study, a multicenter epidemiologic group studying neuroAIDS. He currently is co-PI for the Vanderbilt AIDS Clinical Trials Unit, which includes the Washington University Clinical Research Site. He has a specific focus on understanding the interaction of aging in the setting of chronic HIV infection. Dr Clifford is also the Principal Investigator for the Washington University NeuroNEXT trial unit, one of 25 centers designed to accelerate Phase 2 clinical trials for neurological disorders. He have led international research relevant to HIV and the nervous system in Ethiopia, Uganda, The Gambia, Guinea Bissau, Senegal, and Thailand. He is also currently participating as an investigator at the Knight Alzheimer Disease Research projects at Washington University, and is Medical Director for the Dominant Inherited Alzheimer Disease (DIAN) Treatment Trial (DIAN-TU), the first pre-symptomatic controlled trial for treatment to prevent the onset of dementia in the inherited form of Alzheimer Disease.