Current Lab Members (by project)
Characterization of amyloid-beta oligomers
|Thomas J. Esparza, Senior Technician and Lab Manager (2007-) email@example.com
TJ is working on the development of methods for improved purification of Alzheimer’s disease proteins for downstream characterization within our research group. Our goal is to identify potential therapeutic targets which are primarily responsible to toxicity throughout the disease course.
|Hao Jiang, PhD. Post-doctoral fellow (2014-) firstname.lastname@example.org
Hao is currently working on two major projects. The first is focused on identification of synaptic toxic components in Alzheimer’s diseases patient tissue, by developing a live-cell imaging based synaptic toxicity assay using primary neurons with endogenous fluorescent synaptic proteins. The second project involves purification of amyloid-beta oligomers from human and mouse brain and structural characterization of amyloid-beta oligomers with chemical and biochemical approaches.
|Norelle Wildburger, PhD Post-doctoral fellow (2015-) email@example.com
Norelle is focused on the analysis of Alzheimer’s disease proteins by mass spectrometry. Her goal is to identify proteins primarily responsible for toxicity throughout the disease course, which can be targeted with novel therapeutics.
Characterization of Microglial Cells in Mouse Models of Alzheimer’s disease
|Myles Fountain, Technician (2016-) firstname.lastname@example.org
Myles is working on characterizing microglial phenotypes based on their surface and intracellular markers. In doing so, he hopes that this information could be used by pharmaceutical companies to craft better, more specifically targeted therapeutics.
Mechanisms of amyloid-beta and tau pathologies
|Xianfang Rong, PhD. Post-doctoral fellow (2014-) email@example.com
Xianfang is working to quantify amyloid-beta oligomers in mice following age and traumatic brain injury.
Detection of TBI pathology using advanced diffusion imaging
|Joong Hee ‘Caleb’ Kim, PhD. Research Instructor (2013-) firstname.lastname@example.org
Caleb is a research instructor working to develop advanced diffusion imaging methods in both ex vivo human brain tissue and in vivo mouse brain. He is also interested in the development and application of these advanced diffusion MRI methods to the human brain in vivo.
|Mihika Gangolli PhD, Biomedical Engineering PhD Student (2014-) email@example.com
Mihika is developing quantitative radiological-pathological correlation methods in human brain tissue and implementing these methods to perform radiological-pathological correlations in chronic traumatic encephalopathy (CTE). These methods include histology to MRI image coregistration and the development of histology derived metrics which can then be correlated to advanced diffusion MRI data. She is also working on developing an animal model of chronic traumatic encephalopathy (CTE) using a repetitive concussive injury paradigm in transgenic mice.
|Shan Siddiqi, MD Resident physician in Psychiatry (2015-) firstname.lastname@example.org
Dr. Siddiqi is a psychiatry resident interested in the use of neuroimaging and non-invasive electromagnetic brain stimulation techniques to study the dynamics of neural networks with the goal of applying theoretical/computational network models in translational experiments. His research is focused on the use of repetitive transcranial magnetic stimulation (rTMS) for precision targeting and modulation of fMRI-based resting-state functional connectivity in patients with neuropsychiatric manifestations of TBI. He is currently spearheading a randomized-controlled trial of individualized connectome mapping to target rTMS for treatment-resistant depression in TBI patients.
|Terrance Kummer, MD PhD. Assistant Professor of Neurology (2012-) email@example.com
Dr. Kummer’s research is focused on understanding the mechanisms underlying neuronal trauma and degeneration during and following acute brain injury through the use of advanced brain imaging and monitoring techniques available both in the laboratory and in the clinical setting. Current work includes studying dendritic injury following traumatic brain injury, and severe traumatic brain injury using a rotational acceleration model of traumatic brain injury in mice.
|Andrew Sauerbeck, PhD. Post-doctoral fellow (2015-) firstname.lastname@example.org
Andrew is developing a mouse model of severe traumatic brain injury using a rotational acceleration model. He is studying the resulting dendritic injury that occurs, and is also interested in the characterization of microglia following traumatic brain injury.
|Richard Davenport: technician (2016-) email@example.com
Rich assists Terry and Andrew with behavioral and histopathological analysis of the aforementioned rotational acceleration model.
|Stuart Friess, MD. Assistant Professor of Pediatrics (2012-) Friess_S@kids.wustl.edu
Dr. Friess has a strong background in translational neurocritical care with specific training and expertise in large and small animal modelling of traumatic brain injury. Previous work has included developing neurobehavioral outcome measures in a swine model of head injury and multimodal intracranial monitoring in swine models of traumatic brain injury and cardiac arrest. Currently, Dr. Friess’s research is focused on studying the effects of delayed secondary insults on white matter injury following traumatic brain injury.
|McKenzie Davies,: technician (2016-) firstname.lastname@example.org
McKenzie is using histological staining methods and neurobehavioral outcome measures to study the effects of delayed hypoxia on white matter injury following traumatic brain injury in a mouse model.
Erik Hsu, Undergraduate student (2015-) email@example.com
Alissa Ling, Undergraduate student (Summer 2016) firstname.lastname@example.org
Angela Lumba, MD. Instructor of Pediatric Emergency Medicine (2012-) Lumba_A@kids.wustl.edu
Uma Parikh, Undergraduate student (2013-) email@example.com
Marlene Kanmogne, Bachelor’s in Neuroscience, Rotation student (Summer 2016) firstname.lastname@example.org
Hao Chen, Bachelor’s in Biology, Rotation student (Fall 2016) email@example.com
Alicia Liu, Undergraduate student (2016-) firstname.lastname@example.org