Current Lab Members (by project)
Characterization of amyloid-beta oligomers
|Thomas J. Esparza, Senior Technician and Lab Manager (2007-) email@example.com
TJ is working on the development of methods for improved purification of Alzheimer’s disease proteins for downstream characterization within our research group. Our goal is to identify potential therapeutic targets which are primarily responsible to toxicity throughout the disease course.
|Hao Jiang, PhD. Post-doctoral fellow (2014-) firstname.lastname@example.org
Hao is currently working on two major projects. The first is focused on identification of synaptic toxic components in Alzheimer’s diseases patient tissue, by developing a live-cell imaging based synaptic toxicity assay using primary neurons with endogenous fluorescent synaptic proteins. The second project involves purification of amyloid-beta oligomers from human and mouse brain and structural characterization of amyloid-beta oligomers with chemical and biochemical approaches.
|Norelle Wildburger, PhD Post-doctoral fellow (2015-) email@example.com
Norelle is focused on the analysis of Alzheimer’s disease proteins by mass spectrometry. Her goal is to identify proteins primarily responsible for toxicity throughout the disease course, which can be targeted with novel therapeutics.
Mechanisms of amyloid-beta and tau pathologies
|Xianfang Rong, PhD. Post-doctoral fellow (2014-) firstname.lastname@example.org
Xianfang is working to quantify amyloid-beta oligomers in mice following age and traumatic brain injury.
|Theodore G. Floros. Technician (2014-) email@example.com
Ted is currently focused on utilizing Array Tomography and standard immunohistochemistry to study dendritic and axonal injury after concussion and traumatic brain injury within mouse models. Previously, Ted has worked on the synaptotoxic effects of Amyloid-Beta Oligomers and assisted with other projects within the lab.
Detection of TBI pathology using advanced diffusion imaging
|Joong Hee ‘Caleb’ Kim, PhD. Research Instructor (2013-) firstname.lastname@example.org
Caleb is a research instructor working to develop advanced diffusion imaging methods in both ex vivo human brain tissue and in vivo mouse brain. He is also interested in the development and application of these advanced diffusion MRI methods to the human brain in vivo.
|Laurena Holleran, PhD. Post-doctoral fellow (2014-) email@example.com
Laurena is focused on quantitative radiological-pathological correlations in chronic traumatic encephalopathy (CTE) using advanced diffusion MRI. Additionally, she is also interested in investigating whether these advanced imaging methods are applicable in a clinical setting with the long term goal of using noninvasive methods to diagnose CTE in living patients.
|Mihika Gangolli. Biomedical Engineering PhD Student (2014-) firstname.lastname@example.org
Mihika is working to develop quantitative radiological-pathological correlation methods in brain tissue. These methods include histology to MRI image coregistration and the development of histology derived metrics which can then be correlated to advanced diffusion MRI data. She is also interested in application of these methods to an in vivo traumatic brain injury model to determine whether advanced diffusion MRI correlates of histological markers can be used to predict long term PTSD, depressive, and anxiety-related behavior.
|Terrance Kummer, MD PhD. Assistant Professor of Neurology (2012-) email@example.com
Dr. Kummer’s research is focused on understanding the mechanisms underlying neuronal trauma and degeneration during and following acute brain injury through the use of advanced brain imaging and monitoring techniques available both in the laboratory and in the clinical setting. Current work includes studying dendritic injury following traumatic brain injury, and severe traumatic brain injury using a rotational acceleration model of traumatic brain injury in mice.
|Andrew Sauerbeck, PhD. Post-doctoral fellow (2015-) firstname.lastname@example.org
Andrew is developing a mouse model of severe traumatic brain injury using a rotational acceleration model. He is studying the resulting dendritic injury that occurs, and is also interested in the characterization of microglia following traumatic brain injury.
|Stuart Friess, MD. Assistant Professor of Pediatrics (2012-) Friess_S@kids.wustl.edu
Dr. Friess has a strong background in translational neurocritical care with specific training and expertise in large and small animal modelling of traumatic brain injury. Previous work has included developing neurobehavioral outcome measures in a swine model of head injury and multimodal intracranial monitoring in swine models of traumatic brain injury and cardiac arrest. Currently, Dr. Friess’s research is focused on studying the effects of delayed secondary insults on white matter injury following traumatic brain injury.
|Addison Jacobs: technician (2015-) Jacobs_A@kids.wustl.edu
Addison is using histological staining methods and neurobehavioral outcome measures to study the effects of delayed hypoxia on white matter injury following traumatic brain injury in a mouse model.
Alejandra Camacho-Soto, MD, Instructor of Neurology, PM&R (2015-) email@example.com
Paul Jang, BME PhD rotation student (2015-) firstname.lastname@example.org
Allison Soung, Neuroscience PhD rotation student (2015-) email@example.com
Anna Noronha, Undergraduate student (2015-) firstname.lastname@example.org
Lisa Soumekh, Undergraduate student (2015-) email@example.com
Kara Skjoldager, Undergraduate student (2015-) firstname.lastname@example.org
Erik Hsu: Undergraduate student (2015-) email@example.com
Angela Lumba, MD. Instructor of Pediatric Emergency Medicine (2012-) Lumba_A@kids.wustl.edu
Uma Parikh, Undergraduate student (2013-) firstname.lastname@example.org
Simi Ghosh, PhD. Post-doctoral fellow (2014-) email@example.com