Current Lab Members
Amanda serves as the Administrative Coordinator for Dr. Randall Bateman and the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU). She manages Dr. Randall Bateman’s schedule, correspondence, and travel as well as scheduling and meeting arrangements for the DIAN-TU and Bateman Lab. She has been with Washington University and the Bateman Lab since 2013.
|Wendy Sigurdson, BScN, MHSc, RN
Wendy is a Clinical Research Nurse in Neurology and has been with Dr. Bateman since April of 2007. Prior work experience includes Research for the Department of Neurosurgery. She received her BScN at McMaster University in Canada and her MHSc here at Washington University. Her focus is DIAN and DIAN-TU, but also assists with the ongoing A-beta and Tau studies. She enjoys working with Dr. Bateman and the team because of the amazing, cutting edge research.
|Tamara Donahue, BSN, MS, RN
Tamera is a Clinical Research Nurse Coordinator in Neurology. Current studies include DIAN, DIAN-TU, and A-beta/ tau studies in Dr. Bateman’s lab. She completed her Diploma Nurses training at The Jewish Hospital School of Nursing, her Bachelor of Science degree in nursing at University of MO, St. Louis and a master’s degree in Clinical Research Management at Washington University. Her career has spanned various areas of clinical and research nursing including Cardiology, Imaging, Cardiothoracic Surgery and Neurology.
Melissa has been with Washington University for over 11 years and joined the Bateman lab in 2015. Melissa manages and coordinates the Bateman Lab studies. She collaborates with many different departments such as CARS unit, Dietary, Anesthesia, ADRC, and Imaging to complete studies successfully. Melissa prides herself on the relationships that are built with participants and ensures that they are given the utmost respect when contributing to Bateman research.
|Norelle Wildburger, Ph.D.
Norelle is a joint post-doctoral fellow between the Bateman and Brody labs. Her work in the Bateman lab focuses on using SILK-SIMS imaging of labeling human AD brain to determine amyloid-beta kinetics.
|Nicolas Barthélemy, Ph.D.
Dr. Barthélemy obtained his Ph.D. degree in Analytical Chemistry from the University of Strasbourg. He specializes in protein characterization and quantitation by mass spectrometry. He joined Dr. Bateman’s laboratory as Postdoctoral Associate in 2015 and is pursuing his research on tau protein implication in Alzheimer Disease and others tauopathies.
|Chihiro Sato, Ph.D.,
Dr. Sato is a Research Instructor in the Department of Neurology. She is currently researching the kinetics of tau in the human central nervous system in vivo and in vitro. She is also interested in studying tau profile in Alzheimer’s disease and various tauopathies hoping to improve early diagnostics. https://neuro.wustl.edu/biographies/chihiro-sato/
|Kwasi G. Mawuenyega, Ph.D.
Kwasi joined the Bateman team in 2006. He is a biochemist and bioanalytical chemist specializing in the characterization and quantification of proteins by mass spectrometry. He oversees all proteomics method development in the lab. Specifically, he is responsible for conducting mass spectrometry analyses, overseeing the maintenance of the machines and identifying new mass spectrometry technologies to incorporate into the lab. Project areas include the development of methods for simultaneous measurement of Aß isoforms in human CSF and plasma to enable SILK and pharmacodynamics studies in Alzheimer’s disease. He also collaborates with Dr. Tim Miller to study the kinetics and pharmacodynamics of SOD1 protein in ALS in humans and rat models.As the lab safety manager, Kwasi is also responsible for lab safety compliance with the general principles of working with laboratory chemicals and biological materials.
|Tom Kasten, Ph.D.
Tom has been with Washington University for over 6 years and joined the Bateman lab in 2009. He is lab manager, and a research biochemist involved in the processing of samples for the liquid chromatography/mass spectrophotometer system. Tom is a wealth of information and can assist anyone in the lab from students to physicians on a wide variety of issues. His research interests include human turnover of the amyloid beta (Aβ) protein in Alzheimer’s Disease (AD) in both CSF and plasma.
|Brendan Lucey, MD
Dr. Lucey is an Assistant Professor in the Department of Neurology, sleep medicine division. He is a KL2 scholar pursuing a Master of Science degree in Clinical Investigation. Dr. Lucey’s research investigates how changes in sleep-wake activity alter amyloid-beta concentrations and kinetics. https://neuro.wustl.edu/biographies/brendan-lucey-md/
|Terry Hicks, BS
Terry joined the Bateman lab in 2014 as a research assistant. She primarily works on Dr. Lucey’s studies investigating changes in sleep and amyloid beta kinetics using mass spectrometry. She also aids the Bateman team in method development for measuring amyloid beta in human plasma.
|Katrina Paumier, Ph.D.
Dr. Paumier received her undergraduate training in psychology at the University of Illinois Champaign-Urbana and her PhD in neuroscience from the University of Cincinnati. She then completed her postdoctoral training in the laboratories of Dr. John Dunlop and Dr. Warren Hirst at Pfizer Inc, where she focused on autophagy enhancers for Parkinson’s disease. She was previously an Assistant Professor on the neuroscience faculty at Michigan State University where she focused on treatment strategies for Parkinson’s disease. Dr. Paumier joined the Bateman team in 2015 and is actively involved in several research activities related to misfolded proteins involved in neurodegeneration including alpha-synuclein and amyloid-beta. At present, Dr. Paumier contributes to several studies including: 1) Development of a stable isotope labeling kinetic (SILK) method to measure the turnover rate of alpha-synuclein in human CSF; 2) Investigation of genetic protective factors against Alzheimer’s disease; 3) Examination of effects of ApoE4 on beta-amyloid clearance in the human central nervous system. She also serves as the Administrative Core Leader and Deputy Director of the Dominantly Inherited Alzheimer’s Network (DIAN). In this role, Dr. Paumier helps coordinate efforts and facilitates the day-to-day progress toward the core goals of the DIAN observational study (grant # U19AG032438).
|James Bollinger, Ph.D.
Dr. Bollinger’s studies have focused on the development and application of novel analytical techniques for the profiling of enzymes of clinical relevance. Specifically, he has utilized the triple-quadrupole ESI-MS/MS analytical platform to design reagents and assays that enable the sensitive and specific analysis of individual proteins as well as metabolite profiles derived from their enzymatic activity. In collaboration with multiple other labs, he has applied these assays to characterize relative abundance and kinetic profiles of several proteins with the greater intent of investigating in vivo roles in cellular homeostasis and disease progression. Current efforts in the Bateman lab are focused on IP-LC/MS method development for the assessment of alpha synuclein protein turnover kinetics in human cerebrospinal fluid.
Kate Walter is a third year undergraduate at Boston College majoring in Psychology. Driven by an interest in neuroscience and Alzheimer disease, she joined the Bateman lab summer of 2015 to study the effects of apolipoprotein E-4 (ApoE4) genotype on amyloid-beta (Aß)kinetics. After graduating, Kate hopes to pursue an MD program. While not studying or working in the lab, Kate enjoys running, hiking, horseback riding, and road trips.
Project Title: Apolipoprotein E-4 Perturbation of ß-Amyloid Clearance in the Human Central Nervous System
Paul Moiseyev is a third year undergraduate at Washington University in St. Louis pursuing majors in Philosophy-Neuroscience-Psychology and Biology along with a Minor in Biomedical Physics. Interests in Biochemistry and Neurodegenerative disorders led Paul to join the Bateman lab in the Summer of 2016. He is studying how the processing of Microtubule Associated Protein Tau changes in Alzheimer Disease. After graduation, Paul plans to spend a year working as medical scribe along with being a volunteer tutor. Afterwards, he hopes to pursue an MD. Outside of lab, Paul enjoys teaching, urban exploration, and taking hiking/biking trips through the gorgeous Missouri countryside.
Project Title: Establishing a Comprehensive, Qualitative Profile of Tau in the Human Brain, CSF, and Cell Culture Models
Kaylan Tripathy is currently an MD/PhD student in the Neuroscience graduate program at Wash U. Previously, he worked with Drs. Virginia Lee and John Trojanowski at Penn on the role of TDP-43 in neurodegenerative disease pathogenesis, and with Drs. Brad Schlaggar and Steve Petersen at Wash U on cortical parcellation in children using resting state functional connectivity. Kaylan’s summer 2016 rotation project was to refine a purification scheme and apply newer mass spectrometry approaches to study the full range of amyloid beta proteoforms found in human cerebrospinal fluid. Prior and ongoing work in the lab has looked for these proteoforms by studying intact (undigested) a-beta in Alzheimer’s disease patient brains. His project aimed to take a top-down approach to look for these species by studying intact a-beta in human CSF. The goal is to eventually identify a fingerprint for Alzheimer’s disease, wherein valuable diagnostic and prognostic information can be extracted from the levels of various a-beta proteoforms in a patient’s CSF. In the process, we would also glean valuable information about the pathophysiology of Alzheimer’s disease. Outside of the lab, Kaylan volunteers with a few community service projects focused on medical care and teaching, and he also sings and plays guitar as part of a student band.
Project Title: Studying intact amyloid-beta proteoforms in human CSF
Nipun Mallipeddi is a first year undergraduate at Washington University in St. Louis. Interests in clinical research and neuroscience led him to join the Bateman lab in the summer of 2017. He is helping with the Tau project to study how Tau kinetics change in the CSF of AD and Tauopathy patients. After college, he hopes to pursue an MD. Outside of the lab, Nipun enjoys learning about animals, reading, and coding.
Samani Upadhyay is a third year undergraduate at Brown University majoring in Neuroscience and Contemplative Studies. Driven by an interest in combining medicine and Neurodegenerative disease research, she joined the Bateman lab in the summer of 2017 to study plasma abeta biomarkers. Her project is centered around identifying and characterizing novel abeta isoforms as potential biomarkers that may differ with AD status. After graduating, Samani hopes to pursue an MD/PhD. Her favorite activities outside of lab include hiking, rock climbing, and eating food.
David Wang is a recent graduate of Vanderbilt University with majors in Molecular and Cellular Biology and Spanish. His current project focuses on the optimization and development of plasma AB as a clinical biomarker for Alzheimer’s disease. Specifically, he is investigating lower volumes of plasma for AB detection and quantitation as well as looking at ways to maximize the recovery of AB protein from plasma. He will be pursuing an MD degree at Carver College of Medicine. Outside of the lab, he enjoys traveling, exercising and improving his fluency in Spanish and Chinese.
Jason Shao is a fourth-year undergraduate at Washington University in St. Louis majoring in Biochemistry and minoring in Computer Science. He joined the Bateman lab in Spring of 2017 because of his interests in neuroscience and pathology. Jason is studying the kinetics of amyloid-beta (Aß) deposition and the turnover rate of insoluble Aß deposits in Alzheimer’s patients. He hopes to pursue an MD after graduating. In his free time, Jason enjoys soccer, tennis, teaching, and spending time with friends.
Project Title: Insoluble Aß Kinetics in the Human Brain