Projects

Goals: To understand changes in network connections underlying healthy aging and neurodegeneration and to develop novel therapies for neurodegenerative diseases.

Current projects:

  1. Are certain networks affected in Alzheimer’s Disease (AD) using fMRI?
    The ability to identify certain areas that are affected in AD could lead to development of particular therapies. The goal of this work is to identify early changes in the brain due to AD using multiple neuroimaging modalities (including resting state functional connectivity, arterial spin labeling measurements of cerebral blood flow, diffusion tensor imaging, and structural imaging.
  2. What are the changes in brain associated with HIV Associated Neurocognitive Disorders (HAND) using neuroimaging?
    Individuals infected with HIV are now living longer due to recent advances in highly active antiretroviral therapy (HAART). Both cortical and subcortical changes are now seen with HAND. The goal of this work is to identify early changes in the brain due to HIV using multiple neuroimaging modalities (including resting state functional connectivity, arterial spin labeling measurements of cerebral blood flow, diffusion tensor imaging, and structural imaging.
  3. Can neuroimaging assist in early diagnosis of Cruetzfeld-Jacob Disease (CJD)?
    CJD is a rapidly progressive neurodegenerative disease with diagnosis often made at autopsy. The goal of this work is to identify early changes in the brain structure due to CJD. This may allow for early intervention.If you are an undergraduate student, graduate student, or post-doctoral fellow who is interested in pursuing one of the above projects at Washington University in Saint Louis, please contact Dr. Ances (ancesb@wustl.edu).