Use of PIB PET imaging to evaluate dementia subtypes in patients with Parkinson Disease

WHAT IS THE TITLE OF THE STUDY?

Use of PIB PET imaging to evaluate dementia subtypes in patients with Parkinson Disease

WHAT IS THE PURPOSE OF THE STUDY?

This study will help us determine causes of and progression of dementia (thinking problems) in volunteers with Parkinson Disease (PD) versus healthy control volunteers.

WHO IS NEEDED?

  1. Volunteers must either be diagnosed with PD OR be healthy with no PD and with no first degree family member who has PD.
  2. PD volunteers can be from across the spectrum from no memory impairment all the way to severe memory impairment
  3. Healthy volunteers must not have any neurological problems such as a history of stroke, seizures or movement disorders like tremors or tics.
  4. PD volunteers may not have a history of other neurological problems besides PD such as stroke.
  5. All subjects must be able and willing to lie flat in an MRI scanner and a PET scanner for about one hour each.
  6. People with certain metal in their bodies (like aneurysm clips or cardiac pacemakers) would be excluded.
  7. All subjects must not have any other serious systemic health problems such as cancer, kidney failure, etc.

WHAT IS INVOLVED IF I PARTICIPATE?

Duration: This study involves having a neurological exam, playing memory and thinking games, doing an interview with a loved one about your thinking and memory, having an MRI and having a PET scan. While the PET scan is done only once, the MRI, the memory and thinking games, the annual interview, and the neurological exam are repeated annually. If you chose to participate in this study, you must agree to donate your brain to the Movement Disorder Centers and Dr. Joel Perlmutter at the time of your death.
Tests/Procedures: neurological exam and PD ratings, questionnaires, memory and thinking games, interviews, MRI, PET scan, blood drawing, brain donation.

Risks: Risks will be discussed with volunteers as part of the informed consent process.
Benefits: Participation might help future patients with PD. If abnormalities were found on your MRI, we would alert you and your physician. You would get free feedback on your memory and thinking and a free exam by a movement disorders specialist.

Compensation: Subjects are compensated $150 for time and inconvenience for the first year, and $50 for time and inconvenience for subsequent yearly visits

WHO IS THE PRINCIPAL INVESTIGATOR (DOCTOR)?

Joel S. Perlmutter, MD

WHERE WILL THE STUDY TAKE PLACE?

Washington University School of Medicine

Contact Information:

Coordinator Name: Johanna Hartlein, Advance Practice Registered Nurse
Tel: (314) 362-0420 Email: johanna@npg.wustl.edu