Role of Dopamine Receptors in Primary Focal Dystonias

WHAT IS THE TITLE OF THE STUDY?

Role of dopamine receptors in primary focal dystonias

WHAT IS THE PURPOSE OF THE STUDY?

This study will look at the way the brain works between people with and without focal dystonia (arm or cranial) using brain imaging.

WHO IS NEEDED?

Volunteers must either be healthy adults or adults diagnosed with focal arm or cranial dystonia.

WHAT IS INVOLVED IF I PARTICIPATE?

Duration: Your participation will involve a screening visit and a study visit. Both visits occur on the same day. This study involves a screening visit consisting of a health history and neurological exam. This is similar to the questions you are asked during an office visit for a “complete physical”. The neurological exam includes checking your reflexes, testing your coordination, sensation, and muscle strength.
You will answer brief mood and memory questionnaires. You will also have an MRI and PET scan of the brain.

Tests/Procedures: neurological exam, questionnaires, MRI, and PET scan

Risks: Risks will be discussed with volunteers as part of the informed consent process.

Benefits: Participation might help other people because in the coming years, the information from this study may aid the clinical management of patients with dystonia.

Compensation: Volunteers that complete the study are compensated $200 for their time and inconvenience. If you do not complete both scans, you will be paid for the scans that you do complete.

WHO IS THE PRINCIPAL INVESTIGATOR (DOCTOR)?

Morvarid Karimi, MD

WHERE WILL THE STUDY TAKE PLACE?

Washington University School of Medicine

Contact Information:

Coordinator Name: Stacy Pratt
Tel: (314) 747-5916
Email: pratts@npg.wustl.edu