Effects of Dopamine on Functional Connectivity in Parkinson Disease
WHAT IS THE TITLE OF THE STUDY?
Effects of Dopamine on Functional Connectivity in Parkinson Disease (PD)
WHAT IS THE PURPOSE OF THE STUDY?
This study will help us to gain a better understanding of brain function in Parkinson patients and the effects of medication on activities of certain brain regions in Parkinson patients compared to healthy volunteers.
WHO IS NEEDED?
- Both men and women at least 30 years of age who are free of neurological and psychiatric diseases (control participants). These participants must not have any neurological problems such as a history of stroke, seizures or movement disorders like tremors or tics; or other serious systemic disorders such as current cancer or end stage organ failure.
- Both men and women at least 30 years of age, who are diagnosed with definite PD. These participants MUST NOT use any of anti-Parkinsonian medication for more than 1 week during the month prior to the study, neither should they use any anti-psychotic medications within the past 3 months; or other serious neurological problems like a history of stroke or seizures; or other serious systemic disorders such as current cancer or end stage heart failure.
- All participants must be able and willing to lie still in an MRI scanner for about 90 minutes.
- People with certain metal in their bodies (like aneurysm clips or cardiac pacemakers) would be excluded.
- Individuals who are pregnant or lactating, or have any severe systemic diseases such as cancer, kidney failure, etc are excluded from this study.
WHAT IS INVOLVED IF I PARTICIPATE?
Duration: This study involves two study visits. Each visit will last up to 4 hours.
Tests/Procedures: Drug administration, neurological exam that will be videotaped, questionnaires, memory and thinking tasks, interviews, MRI, blood drawing.
Risks: Risks will be discussed with volunteers as part of the informed consent process.
Benefits: Participation might help future patients with PD. If abnormalities were found on your MRI, we would alert you and your physician.
Compensation: Subjects are compensated $25 per hour for participation in this study for time and inconvenience, up to a total of $200 for completion of the entire study. If participants do not complete the entire study, they will still be paid on an hourly basis.
WHO IS THE PRINCIPAL INVESTIGATOR (DOCTOR)?
Joel Perlmutter, MD
WHERE WILL THE STUDY TAKE PLACE?
Washington University School of Medicine
Johanna Hartlein, Advance Practice Registered Nurse
Tel: (314) 362-0420 Email: firstname.lastname@example.org