David M. Holtzman, MD

David Holtzman received his BS (1983) and MD (1985) from Northwestern University followed by a Neurology residency at UCSF from 1985-1989. He did post-doctoral research at UCSF from 1989-1994. There in addition to his research, he founded a Memory Disorders clinic. He moved to Washington University in 1994 as an Assistant Professor to both start his own lab as well as to get involved in clinical activities and teaching. He is currently Professor and Chair of Neurology, scientific director of the Hope Center for Neurological Disorders, and Associate Director of the Knight ADRC. Some of his and his lab’s accomplishments include showing in part how apoE4 contributes to AD, development of a method to measure protein synthesis and clearance in the CNS of animals and humans, development of CSF biomarkers for AD, demonstration of how synaptic/neuronal activity and sleep affect amyloid-β (Aβ) and tau levels dynamically in vivo acutely and chronically, and development of an anti-Aβ antibody now in 3 phase III trials for AD and an anti-tau antibody in phase 2 clinical trials for AD. He has received a number of honors including being a recipient of a Paul Beeson Physician Faculty Scholar award in Aging research, the Potamkin prize from the American Academy of Neurology for research on Alzheimer’s disease, the MetLife award for Alzheimer’s disease research, a MERIT award from the NIA, election to the National Academy of Medicine of the National Academy of Sciences, election to the National Academy of Inventors, an alumni merit award from the Northwestern Feinberg School of Medicine, being appointed to the National Advisory council of the NINDS and NIA, the Chancellor’s award for innovation and entrepreneurship and the Carl and Gerty Cori award from Washington University, being elected Fellow of the AAAS, and being the past president of the American Neurological Association. Holtzman has trained over 60 graduate students, post-doctoral fellows, and physician-scientists, many of whom have gone on to successful careers in academia and industry.