Terrance Kummer, MD, PhD

Assistant Professor of Neurology

Phone314-362-2999

Emailkummert@neuro.wustl.edu

Board Certifications

  • Board Certification - Neurology

Publications

  • Kummer TT, Misgeld T, Sanes JR (2006). Neuromuscular synaptogenesis: paradigm lost. Current Opinion in Neurobiology.16(1):74-82.
  • Misgeld T*,Kummer TT*, Lichtman JW, Sanes JR (2005). Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter. PNAS. 102: 11088-93.
  • Kishi M,Kummer TT, Eglen SJ, Sanes JR (2005). LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction.J Cell Biol. 169(2):355-66.
  • Kummer TT, Misgeld T, Lichtman JW, Sanes JR (2004). Nerve-independent formation of a topologically complex postsynaptic apparatus.J Cell Biol. 164(7):1077-87.
  • Kummer TT, Nishimune H, Sanes JR (2002). Spotted substrates for focal presentation of proteins to cells. Biotechniques. 33(5):1018-20.
  • Ivanova L, Barmada S,Kummer T, Harris DA (2001). Mutant prion proteins are partially retained in the endoplasmic reticulum.J Biol Chem. 276(45):42409-21.
  • Kummer TT, Ropper AH (2010). Acute Intracranial Hypertension. Pocket Neurology. 45-51.
  • Kummer TT, Westover MB, Cho, TA (2010). Central Nervous System Vasculitis. Pocket Neurology. 175-178.
  • Raju DV, Kummer TT, Parker SW (2010). Dizziness and Deafness. Pocket Neurology. 182-188.
  • Kummer TT, Ropper AH. Critical Care Neurology. ACP Medicine. 1-19.

Dr. Kummer’s research program is focused on understanding the mechanisms underlying neuronal trauma and degeneration during and following acute brain injury. Dr. Kummer carries out this research both in the laboratory, and in the Neurointensive Care Unit, where he is an attending. Brain injury is a leading cause of death and disability in the United States. Sudden brain injury usually takes one of two forms: traumatic or vascular. Traumatic brain injury occurs when the head receives a sudden external impact, possibly from an improvised explosive device, a car windshield, or even a barreling linebacker. Victims of such events may develop brain trauma near the site of impact, such as brain contusions, as well as ripple effects that damage the brain diffusely. Diffuse injury most importantly damages the axons that make up the brain’s wiring. Vascular brain injury takes the form of vascular blockage, causing strokes, and the far more deadly vascular rupture, which causes brain hemorrhages. Although an enlarging bleed causes obvious injury to adjacent brain, very little is known about the diffuse brain injury that likely underlies persistent coma and long-term cognitive and emotional impairment after brain hemorrhage. New results from Dr. Kummer’s group suggest that axon injury, so crucial in traumatic brain injury, also occurs during hemorrhagic brain injury. Dr. Kummer’s research is aimed at exploring this connection through the use of advanced brain imaging and neuromonitoring techniques available both in the laboratory and in the clinical setting.