Stefanie Geisler, MD

Assistant Professor of Neurology

Phone314-362-6981

Emailgeislers@wustl.edu

Related Links

Education

  • Medical Degree: Humboldt University Berlin, Germany ()
  • Residency: Washington University, St. Louis, MO (2013)
  • Fellowiship: Neuromuscular Medicine: Washington University, St. Louis, MO (2015)

Board Certifications

  • Neurology and Psychiatry
  • Neuromuscular Medicine

Recognition

  • Research Fellowship for Young Scientists at the Humboldt University Berlin Germany (2001-2002)
  • Tiburtius Award, Berliner Hochschulen, Germany (2004)
  • “Women in Science Fellow Award” National Institutes of Health/National Institute on Drug Abuse (2009)
  • Irwin Levy Prize for Undergraduate Teaching, Department of Neurology, Washington University Saint Louis (2012)
  • American Brain Foundation/American Academy of Neurology Clinical Research Training Fellowship (2014/15)

Clinical Interests

Dr. Geisler sees patients with neuromuscular diseases in the Neuromuscular Clinic at Washington University Saint Louis

Research Interests

Dr. Geisler’s laboratory research focuses on elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies.  The translational goal is to find treatments to prevent axonal degeneration and facilitate regeneration.

Publications

  1. Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A (2016) Prevention of vincristine-induced neuropathy by genetic deletion of SARM1 in mice.  Brain 139:3092-3108
  2. Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A (2016) TMEM 184b promotes axon degeneration and neuromuscular junction maintenance.  J Neurosci 36(17) 4681-9.
  3. Shin JE, Geisler S, DiAntonio A (2014) Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol 252:1-11
  4. Zahm DS, Cheng AY, Lee TJ, Ghobadi CW, Schwartz ZM, Geisler S, Parsely KP, Gruber C, Veh RW (2011). Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. J Comp Neurol. 2011 519(16):3159-318
  5. Brinschwitz K, Dittgen A, Madai VI, Lommel R, Geisler S, Veh RW (2010) Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain. Neuroscience 30;168(2):463-76
  6. Zahm DS, Becker ML, Freiman AJ, Strauch S, Degarmo B, Geisler S, Meredith GE, Marinelli M. (2010). Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the basal forebrain and recalibration of expression Neuropsychopharmacology 35(2):445-63
  7. Geisler S. (2009). Reticular Formation. Encyclopedia of Neuroscience. M. Binder, N. Hirokawa, U. Windhorst (Eds.) Springer-Werlhag, Heidelberg Vol. 4, pp. 3482-3486.
  8. Jhou TC, Geisler S, Marinelli M, DeGarmo BA, Zahm DS (2009). The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J Comp Neurol 513(6):566-596.
  9. Kowski AB, Geisler S, Krauss M, Veh RW. (2008). Differential projections from subfields in the lateral preoptic area to the lateral habenular complex of the rat. J Comp Neurol 507:1465-1478.
  10. Geisler S, Marinelli M, DeGarmo B, Becker ML, Freiman AJ, Beales M, Meredith GE, Zahm DS. (2008). Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacolgy 33:2688-700.
  11. Geisler S, Wise RA (2008). Functional implications of glutamatergic projections to the ventral tegmental area.  Rev. Neurosci.  19: 227 – 245.
  12. Geisler S, Trimble M. (2008) The lateral habenula: no longer neglected. CNS Spectr 13(6):484-489; featured in Psychiatry Weekly July 7, 2008.
  13. Colussi-Mas J, Geisler S, Zimmer L, Zahm DS, Berod A. (2007). Activation of afferents to the ventral tegmental area in response to acute amphetamine: a double-labelling study. Eur J Neurosci 26(4):1011-1025.
  14.  Geisler S, Derst C, Veh RW, Zahm DS. (2007). Glutamatergic afferents of the ventral tegmental area in the rat. J Neurosci 27(21):5730-5743.
  15. Reynolds SM, Geisler S, Berod A, Zahm DS. (2006). Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Eur. J Neurosci 24:188-196.
  16. Geisler S, Zahm DS. (2006). Neurotensin afferents of the ventral tegmental area in the rat: [1] re-examination of the origins and [2] responses to acute psychostimulant and antipsychotic drug administration. Eur J Neurosci 24:116-134.
  17. Geisler S, Bérod A, Zahm DS, Rostène W. (2006). Brain neurotensin, psychostimulants, and stress: Emphasis on neuroanatomical substrates. Peptides, 27:2364-2384.
  18. Geisler S, Zahm DS. (2006). On the retention of neurotensin in the ventral tegmental area (VTA) despite destruction of the main neurotensinergic afferents of the VTA – Implications for the organization of forebrain projections to the VTA. Brain Res., 1087:87-104.
  19. Geisler S, Zahm DS. (2005). Afferents of the ventral tegmental area in the rat – anatomical substratum for integrative functions.  J Comp Neurol 490:270-294.
  20. Geisler S, Andres KHW, Veh RW. (2003). Morphologic and cytochemical criteria for the identification and delineation of individual subnuclei within the lateral habenular complex of the rat. J Comp Neurol 458:78-97.
  21. Geisler S, Heilmann H, Veh RW. (2002). An optimized method for simultaneous demonstration of neurons and myelinated fiber tracts for delineation of individual trunco – and palliothalamic nuclei in the mammalian brain. Histochem Cell Biol 117:69-79.
  22. Geisler S, Lichtinghagen R, Boker KHW, Veh RW. (1997). Differential distribution of five members of the matrix metalloproteinase family and one inhibitor (TIMP-1) in human liver and skin. Cell Tissue Res 289:173-183.