R. Edward Hogan, MD
Director of the Adult Epilepsy Section—Adult Neurology; Professor of Neurology
- Director, Washington University and Barnes-Jewish Epilepsy Center
- Neurology - Certified
- Clinical Neurophysiology - Certified
- Listed in Best Doctors in America, 2009-2013 (Best Doctors, Inc.)
- Roland JL, Hacker CD, Breshears JD, Gaona CM, Hogan RE, Burton H, Corbetta M, Leuthardt EC. Brain mapping in a patient with congenital blindness – a case for multimodal approaches. Front Hum Neurosci. 2013 Jul 31;7:431.
- Bandt SK, Werner N, Dines J, Rashid S, Eisenman LN, Hogan RE, Leuthardt EC, Dowling J. Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: seizure response rates, complications, and neuropsychological outcomes. Epilepsy Behav. 2013 Jul;28(1):17-21.
- Maccotta L, He BJ, Snyder AZ, Eisenman LN, Benzinger TL, Ances BM, Corbetta M, Hogan RE. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin. 2013 Jun 25;2:862-72.
- Breshears JD, Gaona CM, Roland JL, Sharma M, Bundy DT, Shimony JS, Rashid S, Eisenman LN, Hogan RE, Snyder AZ, Leuthardt EC. Mapping sensorimotor cortex with slow cortical potential resting-state networks while awake and under anesthesia. Neurosurgery. 2012 Aug;71(2):305-16; discussion 316.
- Hogan RE, English EA. Epilepsy and brain function: common ideas of Hughlings-Jackson and Wilder Penfield. Epilepsy Behav. 2012 Jul;24(3):311-3.
- Hogan RE. Automated EEG detection algorithms and clinical semiology in epilepsy: importance of correlations. Epilepsy Behav. 2011 Dec;22 Suppl 1:S4-6.
- Bouilleret V, Hogan RE, Velakoulis D, Salzberg M, Wang L, Egan G, O’Brien TJ, Jones NC. Morphometric abnormalities and hyperanxiety in genetically epileptic rats: a model of psychiatric comorbidity? Neuroimage. 2009; 45:267-274.
- Hogan RE, Bouilleret V, Liu YR, Wang L, Williams JP, Jupp B, Myers D, O’Brien TJ. MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique. J Magn Reson Imaging. 2009 May;29(5):1027-34.
- Van Raay L, Morris M, Reed RC, Hogan RE, O’Brien TJ, Dedeurwaerdere S. Discordance between valproate plasma levels and seizure suppression in a genetic rat model of absence epilepsy. Proceedings of the Australian Neuroscience Society. 2008:13: 118.
- Gardner R, Hogan RE. Three-dimensional deformation-based hippocampal surface anatomy, projected on MRI images. Clin Anat. 2005 Oct;18(7):481-7.Hogan RE, Carne RP, Kilpatrick CJ, Cook MJ, Patel A, King L, O’Brien TJ. Hippocampal deformation mapping in MRI-negative PET-positive temporal lobe epilepsy. Journal of Neurology Neurosurgery and Psychiatry. 2008;79:636-640.
- Deduwaerdere S, van Raay L, Morris M, Reed RC, Hogan RE, O’Brien TJ. Relationship of valproate plasma, CSF, and brain pharmacokinetics: Evidence of a direct receptor effect? Neurology. 2008:70(Supl 1):A224.
- Hogan RE, Bouilleret V, Liu YR, Wang L, Williams J, Jupp B, Myers D, O’Brien TJ. MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique. Society for Neuroscience meeting, 2008.
- Van Raay L, Morris M, Reed RC, Hogan RE, O’Brien TJ, Deduwaerdere S. Does intermittent administration of valproate result in better seizure suppression compared to continuous administration in two rat model of epilepsy? Epilepsia 2008:49 (suppl. 7): 108.
- Escandon A, Blackburn S, Hogan, R, Dowling J, Eisenman L, Leuthardt E, Rashid S. Outcomes of selective amygdalohippocampectomy versus anterior temporal lobectomy for intractable mesial temporal lobe epilepsy. Epilepsia 2008:49 (suppl. 7): 279.
- Development and validation of the technique of MRI-based large deformation high dimensional mapping of the hippocampus in rats. Epilepsia 2008:49 (suppl. 7): 364-365.
Dr. Hogan has extensive experience as an investigator in multi-center studies of new medications for patients with refractory epileptic seizures, and has participated in studies of pharmacokinetics and clinical effects of antiepileptic medications.
Interests in semiology (interpretation of signs and symptoms) of epileptic seizures include clinical changes, such as changes in consciousness, during and after seizures. Neuro-imaging interests incorporate use of magnetic resonance imaging (MRI) and application of analytical techniques such as computational anatomy and general pattern theory to outline brain structures, such as the hippocampus. Important potential clinical applications for MRI studies include measurements of neuroanatomical brain changes to assist in diagnosis of different types of epilepsy, and to more precisely document disease progression in patients with chronic epilepsy. Research in neuro-imaging also involves single photon emission computed tomography (SPECT), which allows measurement of brain cerebral blood flow perfusion during seizures, which correlates well with the electrographic pattern of epileptic seizures. For SPECT scanning, computer-aided methods of post-image acquisition processing of ictal and interictal SPECT images, including subtraction ictal SPECT and subtraction ictal SPECT co-registered to MRI (SISCOM) can improve the clinical usefulness of SPECT, and assist in localizing seizures. Goals of his research interests in clinical semiology and neuro-imaging are to improve understanding of epileptic seizures for applications of advanced treatments for seizures, including the surgical treatment of epileptic seizures, which are refractory to traditional treatments such as medications.