Mwiza Ushe, MD
Associate Professor of Neurology
- Ushe M, Perlmutter JS. Sex, drugs and Parkinson’s disease. Brain 2013; 136: 371-373.
- Hill KK, Campbell MC, McNeely ME, Karimi M,Ushe M, Tabbal SD, Hershey T, Flores HP, Hartlein JM, Lugar HM, Revilla FJ, Videen TO, Earhart GM, Perlmutter JS. Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson’s disease. Exp. Neurol. 2013;241:105-112.
- Ushe M, Perlmutter JS. Oromandibular and lingual dystonia associated with spinocerebellar ataxia type 8. Mov Disord 2012; 27: 1741-1742.
- Karimi M, Golchin N, Tabbal SD, Hershey T, Videen TO, Wu J,Ushe M, Revilla FJ, Hartlein JM, Wernle AR, Mink JW, Perlmutter JS. Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease. Brain. 2008 Oct; 131(Pt 10):2710-9.
- Tabbal SD,Ushe M, Mink JW, Revilla FJ, Wernle AR, Hong M, Karimi M, Perlmutter JS. Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease. Exp Neurol. 2008 May; 211(1):234-42.
- Ushe M, Mink JW, Tabbal SD, Hong M, Schneider Gibson P, Rich KM, Lyons KE, Pahwa R, Perlmutter JS. Postural tremor suppression is dependent on thalamic stimulation frequency. Mov Disord. 2006 Aug; 21(8):1290-2.
- Ushe M, Mink JW, Revilla FJ, Wernle A, Schneider Gibson P, McGee-Minnich L, Hong M, Rich KKM, Lyons KE, Pahwa R, Perlmutter JS. Effect of stimulation frequency on tremor suppression in essential tremor. Mov. Disord. 2004 Oct; 19(10):1163-8
Dr. Ushe is interested movement disorders including idiopathic Parkinson disease, multiple systems atrophy, dystonia, essential tremor as well as the spinocerebellar ataxias and Huntington disease. His primary clinical focus is the evaluation of patients for deep brain stimulation (DBS), intraoperative microelectrode recording and testing for the placement of DBS electrodes and postoperative programming and treatment of PD, ET and dystonia patients with DBS. Dr. Ushe works with the stereotactic neurosurgery service in the placement of subthalamic nucleus, ventral intermediate nucleus (VIM) and globus pallidus deep brain stimulating electrodes. He also performs Botulinum toxin injection for dystonia, pediatric dystonia and spasticity as well as sialorrhea. His mentors at Washington University are Dr. Joel S. Perlmutter, MD and Dr. Brad A. Racette, MD.
Dr. Ushe’s research interests include: 1) determining the mechanisms by which deep brain stimulation for movement disorders improves the motor manifestations of PD, ET and dystonia. 2) determining how deep brain stimulation parameters can be adjusted to improve the motor manifestation of PD. 3) the development of objective measurement tools for movement disorders and 4) evaluation of dementia in movement disorders.