Matthew Loftspring, MD, PhD

Assistant Professor of Neurology

Education

  • Undergraduate: DePauw University, Greencastle, IN (2005)
  • MD/PhD (MSTP): University of Cincinnati, Cincinnati, OH (2013)
  • Internship, Internal Medicine: Washington University School of Medicine, St. Louis, MO (2014)
  • Residency, Neurology: Washington University School of Medicine, St. Louis, MO (2017)

Board Certifications

  • Board Eligible, Neurology

Recognition

  • Merit Award, DePauw University (2001-2004)
  • Third place, Cincinnati Translational Neuroscience Symposium (2007)
  • University Graduate Scholarship, University of Cincinnati (2007-2009)
  • Medical Student Scholars Program (MSSP), University of Cincinnati College of Medicine (2007-2013)
  • Medical Student Summer Research Program Fellowship and Third Place Poster, University of Cincinnati College of Medicine (2008)
  • Finalist, Excellence in Teaching Award (a university-wide award for graduate students) (2010)
  • Sponsored Attendee, “How to Combine Research and Clinical Careers in Neuroscience” Symposium, Sponsored by NINDS, AUPN and ANA. Washington, DC. (2011)
  • Sponsored Attendee, “Neurology Residents Scholar Program” in Epilepsy. Dallas, TX. (2016)

Clinical Interests

Stroke, Headache, Epilepsy, Adult Cerebral Palsy, Neuromuscular Disorders, Parkinson Disease and Dementia.

Research Interests

Basic mechanisms of neuroplasticity after stroke.

Publications

Oral Presentations

Mechanisms of Inflammation after Intracerebral Hemorrhage: The Role of Immune Cells in Early Brain Injury. Neurocritical Care Society Annual Meeting, Montreal, Quebec, Canada, 2011.

The immune response to intracerebral hemorrhage: a flow cytometric analysis of infiltrating leukocytes and the effects of bilirubin oxidation products. Society for Neuroscience, Program No. 708.8, Washington DC, 2008.

Peer-Reviewed Publications

Loftspring MC, Kissela BM, Flaherty ML, Khoury JC, Alwell K, Moomaw CJ, Kleindorfer DO, Woo D, Adeoye O, Ferioli S, Broderick JP, Khatri P. Practice Patterns for Acute Ischemic Stroke Workup:

A Longitudinal Population Based Study, J Am Heart Assoc, 2017 Jun 23;6(6).

Loftspring MC, Eldeniz C, Lin W, Ford AL, An H, Lee J-M. Early Improvement in Collateral Flow after Acute Ischemic Stroke is Associated with Larger Penumbral Signature and Improved Clinical Outcomes, in preparation.

Loftspring MC, Yeatts S, Martin RH, Tomsick TA, Broderick JP, Furlan A, Carrozzella J, Khatri P, for the IMS I & II and PROACT II Investigators. Hemorrhagic infarction is not a marker of early reperfusion: an analysis of the IMS I/II and PROACT II Trials, in preparation.

Loftspring MC, Kissela BM, Flaherty ML, Khoury JC, Alwell K, Moomaw CJ, Kleindorfer DO, Woo D, Adeoye O, Ferioli S, Broderick JP, Khatri P. Practice Patterns for Acute Ischemic Stroke Workup:

A Longitudinal Population Based Study, J Am Heart Assoc, accepted, 2017.

Loftspring MC, Landsness E, Wooliscroft L, Rudock R, Jo S, Patel KR. GABAB Encephalitis: A fifty-two-year-old man with seizures, dysautonomia and acute heart failure. Case Rep Neurol Med, 2015:812035, 2015.

Solomon MB*, Loftspring M*, de Kloet A*, Ghosal S, Carvallho-Netto E, Jankord R, Flak J, Wulsin AC, Krause EG, Zhang R, Rice T, McKlveen JM, Myers B, Dolgas C, Packard B, Tasker JG, Herman JP. Neuroendocrine Function Following Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice. Endocrinology, 156:2843-53, 2015. *Contributed equally.

Loftspring MC, Johnson HL, Johnson AJ, Clark JF. Depletion of GR-1-positive cells is associated with reduced neutrophil inflammation and astrocyte reactivity after experimental intracerebral hemorrhage. Transl Stroke Res, 3(Suppl 1):S147–S154, 2012.

Loftspring MC, Johnson HL, Feng R, Johnson AJ, Clark JF. Unconjugated bilirubin contributes to early inflammation and edema after intracerebral hemorrhage. J Cereb Blood Flow Metab, 31: 1133-42, 2011.

Loftspring MC. Iron and early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab, 30: 1791-2, 2010.

Loftspring MC, Hansen C, Clark JF. A novel brain injury mechanism after intracerebral hemorrhage: the interaction between heme products and the immune system. Med Hypotheses, 74: 63-6, 2010.

Clark JF, Loftspring M, Wurster WL, Beiler S, Beiler C, Wagner KR, Pyne-Geithman GJ. Bilirubin oxidation products, oxidative stress and intracerebral hemorrhage. Acta Neurochir suppl, 105: 7-12, 2009.

Loftspring MC, Smanik J, Gardner C, Pixley SK. Selective gray matter staining of human brain slices: optimized use of cadaver materials with long post-mortem intervals. Biotech Histochem, 83: 173-7, 2008.

Loftspring MC, McDole J, Lu A, Clark JF, Johnson AJ. Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes. J Cereb Blood Flow Metab, 29:137-143, 2009.

Clark JF, Loftspring M, Wurster WL, Pyne-Geithman GJ. Chemical and biochemical oxidations in hemorrhagic spinal fluid after subarachnoid hemorrhage. Front Biosci, 13: 1806-1812, 2008.

Loftspring MC, Clark JF, and Wagner KR. A novel duplex ELISA to quantitate plasma proteins in areas of brain edema. Brain Res, 1162: 130-132, 2007.

Loftspring MC, Wurster WL, Pyne-Geithman GJ, Clark, JF. An in vitro model of aneurysmal subarachnoid hemorrhage: oxidation of unconjugated bilirubin by cytochrome oxidase. J Neurochem, 102: 1990-1995, 2007.

Loftspring MC, Beiler S, Beiler C, Wagner KR. Plasma proteins in edematous white matter following intracerebral hemorrhage confound immunoblots: an ELISA to quantify contamination. J Neurotrauma, 23: 1904-1911, 2006.

Goldenberg N, Glueck CJ, Loftspring M, Sherman A, Wang P. Metformin-diet benefits in women with polycystic ovary syndrome in the bottom and top quintiles for insulin resistance. Metabolism, 54: 113-121, 2005.

Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod, 19: 1323-1330, 2004.

Glueck CJ, Goldenberg N, Wang P, Loftspring M, Sherman A. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod, 19: 510-521, 2004.

Book Chapter

Loftspring MC, Bucelli RC. Cranial Neuropathies. In The Washington Manual of Emergency Medicine. Levine M, ed. Philadelphia: Lippincott Williams & Wilkins, 2016.

Selected Abstracts and Poster Presentations

Loftspring MC, Eldeniz C, Lin W, Ford AL, An H and Lee J-M. Dynamic Changes in MR-Defined Collateral Flow After Acute Ischemic Stroke Is Associated With Larger Penumbral Signature and Improved Clinical Outcomes. AHA/ASA International Stroke Conference, Los Angeles, CA, 2016, accepted.

Loftspring MC, Khoury JC, Alwell KA, Moomaw CJ, Kleinforfer DO, Flaherty ML, Woo D, Adeoye O, Ferioli S, Kissela BM, Broderick JP, Khatri P. Temporal Trends in Practice Patterns for Acute Ischemic Stroke Workup: A Population-Based Study. AHA/ASA International Stroke Conference, Honolulu, HI, 2013.

Loftspring MC, Johnson HL, Johnson AJ, Clark JF. Depletion of GR-1-positive cells is associated with reduced neutrophil inflammation and astrocyte reactivity after experimental intracerebral hemorrhage. National MD/PhD Student Conference, Keystone, CO, 2012.

Solomon MB, Loftspring M, de Kloet A, Rice T, Carvallho-Netto E, Wulsin AC, Myers B, McKlveen JM, Herman JP. The role of central glucocorticoid receptors in HPA axis regulation in males and females. Elizabeth Young New Investigator Symposium, Organization for the Study of Sex Differences, Baltimore, MD, 2012.

Loftspring MC, Hansen C, Clark JF. Heme products and inflammation after intracerebral hemorrhage. Society for Neuroscience, Ohio Miami Valley Chapter, Cincinnati, OH, 2010.

Loftspring MC, Hansen C, Clark JF. A model for the role of heme products in the pathogenesis of brain injury following intracerebral hemorrhage. Society for Neuroscience, Program No. 744.3, Chicago, IL, 2009.

Loftspring MC, McDole J, Lu A, Johnson AJ, Clark JF. The immune response to intracerebral hemorrhage: a flow cytometric analysis of infiltrating leukocytes and the effects of bilirubin oxidation products. Society for Neuroscience, Program No. 708.8, Washington DC, 2008.

Wurster WL, Loftspring MC, Clark JF. Bilirubin oxidation products (BOXes) are produced by biochemical oxidation involving free peroxynitrite. Experimental Biology, San Diego, CA, 2008.

Loftspring MC, Clark JF, Wagner KR. A novel duplex ELISA method for the quantitation of plasma proteins in areas of brain edema. Society for Neuroscience, Program No. 593.14, San Diego, CA, 2007.

Pyne-Geithman GJ, Caudell DN, Loftspring M, Clark JF. Glutathione peroxidase activity in cerebral vasospasm after subarachnoid hemorrhage. Atheroscl Thromb and Vasc Biol, 27: e112, 2007. Chicago, IL, 2007.

Loftspring MC, Wurster WL, Pyne-Geithman GJ, Clark, JF. Oxidation of unconjugated bilirubin by cytochrome oxidase: implications for treatment of cerebral vasospasm after subarachnoid hemorrhage. Cincinnati Translational Neuroscience Symposium, 2007.

Loftspring MC, Wurster WL, Pyne-Geithman GJ, Clark, JF. Molecular oxygen is required for the oxidation of bilirubin in vitro. Society for Neuroscience, Program No. 180.5, Atlanta, GA, 2006.

Loftspring MC, Wurster WL, Clark, JF. Oxidation of bilirubin by the hemoglobin/Fenton reaction. Midwest Enzyme Chemistry Conference, Evanston, IL, 2006.

Loftspring MC, Beiler S, Beiler C, Wagner KR. Quantitation of contaminating plasma proteins in brain injury models with interstitial or vasogenic edema development. Society for Neuroscience, Program No. 100.2, Washington, DC, 2005.