Luqi Chi, MD

Associate Professor of Neurology


Board Certifications

  • Internal Medicine
  • Sleep Medicine

Related Links

Clinical Interests

Outpatient consultation and hospital sleep medicine, obstructive sleep apnea, central sleep apnea, treatment adherence issues associated with positive airway pressure therapy, sleep related hypoventilation, obesity hypoventilation syndrome, circadian rhythm disorders, insomnia, hypersomnia, narcolepsy, restless leg syndrome, periodic limb movement disorder, and parasomnias (sleep walking, sleep-related eating disorder, REM behavior disorder, etc).

In addition to treating sleep disorders, Dr. Chi also has expertise in treating patients with chronic respiratory failure/insufficiency caused by neuromuscular disease (such as ALS), chest wall deformity, lung disease and congestive heart failure using noninvasive ventilation (NIV) delivered through a variety of ventilatory modes.


  • Kuna S.T., Shuttleworth D., Chi, L., Schutte-Rodin, S., Friedman, E., Guo H., Dhand, S., Yang, L., Zhu, J., Bellamy, S.L., Volpp, K.G., Asch, D.A. Web-based access to positive airway pressure usage with or without an initial financial incentive improves treatment use in patients with obstructive sleep apnea. Sleep. Accepted: Nov 22, 2014. In press.
  • Chi, L., Comyn, F., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I., Schwab, R.J. Heritability of Craniofacial Structures in Normal Subjects and Patients with Obstructive Sleep Apnea. Sleep. 2014 Oct 1;37(10):1689-98
  • Chi, L., Comyn, F., Mitra, N., Reilly, M.P., Wan, F., Maislin, G., Chmiewski, L., Thorne-FitzGerald, M.D., Victor, U.N., Pack, A.I., Schwab, R.J.: Identification of Craniofacial Risk Factors for Obstructive Sleep Apnea Using Three-Dimensional MRI. Eur Resp J. 2011; 38:348-58
  • Chi, L., Li, Y., Stehno-Bittle, L., Stechschulte, D.J., Dileepan, K.N. Interleukin-6 Production by endothelial cells via protease-activated receptor stimulation is synergized by endotoxin and tumor necrosis factor-alpha. Journal of Interferon and Cytokine Research. 2001; 21:231-240
  • Chi, L., Stehno-Bittel, L., Smirnova., I., Stechschulte, D.J., Dileepan, K.N. Signal transduction pathways in mast cell granule-mediated endothelial cell activation. Mediators Inflamm. 2003; 12:79-87
  • Li, Y., Chi, L., Stechschulte, D.J., Dileepan, K.N.: Histamine-induced production of IL-6 and IL-8 by human coronary artery endothelial cells is enhanced by endotoxin and TNF-alpha. Microvascular Research 2001; 61:253-262


Dr. Chi received her medical degree and a master’s degree in cardiopulmonary pathophysiology in China. She subsequently completed her residency training in internal medicine and fellowship training in pulmonary and critical care medicine. She came to the US in 1998 with the goal of becoming an academic physician. She went on to complete her US residency in Rochester General Hospital and fellowship training in sleep medicine at the University of Pennsylvania School of Medicine. She also received a master’s degree in Clinical Epidemiology (MSCE) at the University of Pennsylvania School of Medicine. Prior to joining Washington University, Dr. Chi practiced sleep medicine in Philadelphia, holding a faculty position at both the University of Pennsylvania School of Medicine and Jefferson Medical College.

In addition to practicing sleep medicine and teaching residents and fellows, Dr. Chi is also an active clinical researcher. She is a principle investigator and co-investigator in several ongoing clinical trials. Dr. Chi’s clinical research interests focus on (1) understanding the mechanisms leading to sleep apnea by examining the role of soft tissue and bonny structures surrounding the upper airway; (2) effectiveness of CPAP therapy (the standard treatment of sleep apnea) on cardiovascular system; and (3) CPAP adherence trials.

Dr. Chi is a principle investigator of the following clinical trials:

  1. Differential upper airway anatomic risk factors between Chinese and Caucasian apneics
  2. The effect of CPAP on cardiac function in hospitalized patients with obstructive sleep apnea and heart failure
  3. Reducing CHF re-admissions by enhancing CPAP adherence

Practice Philosophy

Dr. Chi’s practice philosophy is patient-centered, forming a working partnership with the patient and the patient’s family in which the patient takes an active role in his/her treatment. Dr. Chi offers a multidisciplinary approach and greatly values the patient as an individual. She uses her knowledge, compassion, analytical thinking, and problem solving skills to offer passionate care that leads to the best possible outcome for each patient.

Medical Training

Training in USA:
Residency: Internal Medicine, Rochester General Hospital, 2006
Fellowship: Sleep Medicine: University of Pennsylvania School of Medicine, 2008

Training in China:
Residency: Internal Medicine
Fellowship: Pulmonary and Critical Care Medicine