Kweek L. Thio, MD, PhD

Associate Professor of Neurology



Additional Titles

  • Associate Professor, Pediatrics
  • Associate Professor, Neurobiology

Board Certifications

  • Neurology - Board Qualified
  • Pediatrics - Board Qualified

Related Links


  • Listed in Best Doctors in America, 2007-2013 (Best Doctors, Inc.)


  • He Y, Brunstrom-Hernandez JE, Thio LL, Lackey S, Gaebler-Spira D, Kuroda MM, Stashinko E, Hoon AH Jr, Vargus-Adams J, Stevenson RD, Lowenhaupt S, McLaughlin JF, Christensen A, Dosa NP, Butler M, Schwabe A, Lopez C, Roge D, Kennedy D, Tilton A, Krach LE, Lewandowski A, Dai H, Gaedigk A, Leeder JS, Jusko WJ. Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy. J Pediatr. 2014 May;164(5):1181-1188.e8.
  • Paciorkowski AR, Weisenberg J, Kelley JB, Spencer A, Tuttle E, Ghoneim D, Thio LL, Christian SL, Dobyns WB, Paschal BM. Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. Eur J Hum Genet. 2014 May;22(5):587-93.
  • Vining EP, Thio LL. Absence in childhood absence epilepsy: the horse is out of the barn. Neurology. 2013 Oct 29;81(18):1564-5.
  • Mitchell TJ, Neil JJ, Zempel JM, Thio LL, Inder TE, Bretthorst GL. Automating the analysis of EEG recordings from prematurely-born infants: a Bayesian approach. Clin Neurophysiol. 2013 Mar;124(3):452-61.
  • Hucthagowder V, Liu TC, Paciorkowski AR, Thio LL, Keller MS, Anderson CD, Herman T, Dehner LP, Grange DK, Kulkarni S. Chromosome 2p15p16.1 microdeletion syndrome: 2.5 Mb deletion in a patient with renal anomalies, intractable seizures and a choledochal cyst. Eur J Med Genet. 2012 Aug-Sep;55(8-9):485-9.
  • Thio LL. Hypothalamic hormones and metabolism. Epilepsy Res. 2012 Jul;100(3):245-51.
  • Paciorkowski AR, Thio LL, Dobyns WB. Genetic and biologic classification of infantile spasms. Pediatr Neurol. 2011 Dec;45(6):355-67.
  • Paciorkowski AR, Thio LL, Rosenfeld JA, Gajecka M, Gurnett CA, Kulkarni S, Chung WK, Marsh ED, Gentile M, Reggin JD, Wheless JW, Balasubramanian S, Kumar R, Christian SL, Marini C, Guerrini R, Maltsev N, Shaffer LG, Dobyns WB. Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function. Eur J Hum Genet. 2011 Dec;19(12):1238-45.
  • McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. 2011 Mar;52(3):e7-11.
  • Thio LL, Rensing N, Maloney S, Wozniak DF, Xiong C, Yamada KA. A ketogenic diet does not impair rat behavior or long-term potentiation. Epilepsia. 2010 Aug;51(8):1619-23.
  • Zhang HX, Lyons-Warren A, Thio LL. The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist. Neuropharmacology. 2009 Oct-Nov;57(5-6):551-5.
  • Zhang HX, Hyrc K, Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009 Jul 1;587(Pt 13):3207-20.
  • Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neurosci Lett. 2008 Mar 12;433(2):82-6.
  • Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA. Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest. 2008 Jan;118(1):272-80.
  • Zhang HX, Thio LL. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol. 2007 Dec;98(6):3666-76. Epub 2007 Oct 3.

Dr. Thio is the Director of the Pediatric Epilepsy Center.

Dr. Thio’s research interests are cellular neurophysiology, inhibitory glycine receptors, and ketogenic diet. He holds clinic weekly, is Consultant Pediatric Epileptologist for the Pediatric Cerebral Palsy Center, and serves on the Pharmaceutical, Diagnostics, and Therapeutics Subcommittee at St. Louis Children’s Hospital.