Lawrence N Eisenman, MD, PhD

Associate Professor of Neurology

Phone314-362-7845

Fax314-362-0296

Emailleisenman@wustl.edu

Board Certifications

  • Neurology - Certified
  • Epilepsy - Certified
  • Clinical Neurophysiology - Certified

Research Interests

GABA receptors

Related Links

Publications

  • Emnett CM, Eisenman LN, Taylor AM, Izumi Y, Zorumski CF, Mennerick S. Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine. Mol Pharmacol. 2013 Dec;84(6):935-47.
  • Bandt SK, Werner N, Dines J, Rashid S, Eisenman LN, Hogan RE, Leuthardt EC, Dowling J. Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: seizure response rates, complications, and neuropsychological outcomes. Epilepsy Behav. 2013 Jul;28(1):17-21.
  • Maccotta L, He BJ, Snyder AZ, Eisenman LN, Benzinger TL, Ances BM, Corbetta M, Hogan RE. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin. 2013 Jun 25;2:862-72.
  • Breshears JD, Gaona CM, Roland JL, Sharma M, Bundy DT, Shimony JS, Rashid S, Eisenman LN, Hogan RE, Snyder AZ, Leuthardt EC. Mapping sensorimotor cortex with slow cortical potential resting-state networks while awake and under anesthesia. Neurosurgery. 2012 Aug;71(2):305-16; discussion 316.
  • Rojas P, Akrouh A, Eisenman LN, Mennerick S. Differential effects of axon initial segment and somatodendritic GABAA receptors on excitability measures in rat dentate granule neurons. J Neurophysiol. 2011 Jan;105(1):366-79.
  • Dribben WH, Eisenman LN, Mennerick S. Magnesium induces neuronal apoptosis by suppressing excitability. Cell Death Dis. 2010 Aug 12;1:e63.
  • Chisari M, Eisenman LN, Covey DF, Mennerick S, Zorumski CF. The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci. 2010 Jul;33(7):299-306.
  • Kress GJ, Dowling MJ, Eisenman LN, Mennerick S. Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus. 2010 Apr;20(4):558-71.
  • Mennerick S, Chisari M, Shu HJ, Taylor A, Vasek M, Eisenman LN, Zorumski CF. Diverse voltage-sensitive dyes modulate GABAA receptor function. J Neurosci. 2010 Feb 24;30(8):2871-9.
  • Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Mol Pharmacol. 2009 Oct;76(4):754-65.
  • Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S. The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol. 2009 Aug;102(2):1254-64.
  • Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S. NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. J Physiol. 2009 Jun 15;587(Pt 12):2937-47.
  • Mennerick S, Lamberta M, Shu HJ, Hogins J, Wang C, Covey DF, Eisenman LN, Zorumski CF. Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophys J. 2008 Jul;95(1):176-85.
  • Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nat Neurosci. 2007 Apr;10(4):523-30. Epub 2007 Feb 25.

Dr. Eisenman is an Associate Professor of Neurology specializing in the evaluation and treatment of adults with epilepsy including diagnosis, pharmacological treatment and intensive evaluation for surgical treatment including video/EEG monitoring. In addition, he is the director of the Clinical Neurophysiology Training Program and the recipient of a K08 career development award from the NIH.