Joel S Perlmutter, MD

Chief of the Movement Disorders Section—Adult Neurology; Elliot Stein Family Professor of Neurology



Additional Titles

  • Professor, Occupational Therapy
  • Professor, Physical Therapy
  • Professor, Radiology
  • Professor, Neuroscience

Board Certifications

  • Neurology - Certified

Related Links


  • Listed in Best Doctors in America, 2002-2013 (Best Doctors, Inc.)
  • Listed in America’s Top Doctors, 2002-2012 (Castle Connolly Medical Ltd.)


  • Peterson DS, Pickett KA, Duncan RP, Perlmutter JS, Earhart GM. Brain activity during complex imagined gait tasks in Parkinson disease. Clin Neurophysiol. 2014 May;125(5):995-1005.
  • Fan J, Zhang X, Li J, Jin H, Padakanti PK, Jones LA, Flores HP, Su Y, Perlmutter JS, Tu Z. Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate. Bioorg Med Chem. 2014 May 1;22(9):2648-54.
  • Norris SA, Derdeyn CP, Perlmutter JS. Levodopa-Responsive Hemiparkinsonism Secondary to Cystic Expansion from a Coiled Cerebral Aneurysm. J Neuroimaging. 2014 Apr 7.
  • Semrau JA, Perlmutter JS, Thoroughman KA. Visuomotor adaptation in Parkinson’s disease: Effects of perturbation type and medication state. J Neurophysiol. 2014 Apr 2. [Epub ahead of print]
  • The Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, Griebner B, Watts A, Gao S, Pourcher E, Bond L, Kompoliti K, Agarwal P, Sia C, Jog M, Cole L, Sultana M, Kurlan R, Richard I, Deeley C, Waters CH, Figueroa A, Arkun A, Brodsky M, Ondo WG, Hunter CB, Jimenez-Shahed J, Palao A, Miyasaki JM, So J, Tetrud J, Reys L, Smith K, Singer C, Blenke A, Russell DS, Cotto C, Friedman JH, Lannon M, Zhang L, Drasby E, Kumar R, Subramanian T, Ford DS, Grimes DA, Cote D, Conway J, Siderowf AD, Evatt ML, Sommerfeld B, Lieberman AN, Okun MS, Rodriguez RL, Merritt S, Swartz CL, Martin WR, King P, Stover N, Guthrie S, Watts RL, Ahmed A, Fernandez HH, Winters A, Mari Z, Dawson TM, Dunlop B, Feigin AS, Shannon B, Nirenberg MJ, Ogg M, Ellias SA, Thomas CA, Frei K, Bodis-Wollner I, Glazman S, Mayer T, Hauser RA, Pahwa R, Langhammer A, Ranawaya R, Derwent L, Sethi KD, Farrow B, Prakash R, Litvan I, Robinson A, Sahay A, Gartner M, Hinson VK, Markind S, Pelikan M, Perlmutter JS, Hartlein J, Molho E, Evans S, Adler CH, Duffy A, Lind M, Elmer L, Davis K, Spears J, Wilson S, Leehey MA, Hermanowicz N, Niswonger S, Shill HA, Obradov S, Rajput A, Cowper M, Lessig S, Song D, Fontaine D, Zadikoff C, Williams K, Blindauer KA, Bergholte J, Propsom CS, Stacy MA, Field J, Mihaila D, Chilton M, Uc EY, Sieren J, Simon DK, Kraics L, Silver A, Boyd JT, Hamill RW, Ingvoldstad C, Young J, Thomas K, Kostyk SK, Wojcieszek J, Pfeiffer RF, Panisset M, Beland M, Reich SG, Cines M, Zappala N, Rivest J, Zweig R, Lumina LP, Hilliard CL, Grill S, Kellermann M, Tuite P, Rolandelli S, Kang UJ, Young J, Rao J, Cook MM, Severt L, Boyar K. A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit. JAMA Neurol. 2014 Mar 24.
  • Black KJ, Snyder AZ, Mink JW, Tolia VN, Revilla FJ, Moerlein SM, Perlmutter JS. Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia. PLoS One. 2014 Feb 10;9(2):e88121.
  • Willis AW, Schootman M, Kung N, Wang XY, Perlmutter JS, Racette BA. Disparities in deep brain stimulation surgery among insured elders with Parkinson disease. Neurology. 2014 Jan 14;82(2):163-71.
  • Karimi M, Moerlein SM, Videen TO, Su Y, Flores HP, Perlmutter JS. Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. Mov Disord. 2013 Dec;28(14):2002-6.
  • Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T. A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Synapse. 2013 Nov;67(11):748-56.
  • Brown CA, Karimi MK, Tian L, Flores H, Su Y, Tabbal SD, Loftin SK, Moerlein SM, Perlmutter JS. Validation of midbrain positron emission tomography measures for nigrostriatal neurons in macaques.Ann Neurol. 2013 Oct;74(4):602-10.
  • Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS. Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases. Neurology. 2013 Aug 6;81(6):520-7.
  • Li J, Zhang X, Zhang Z, Padakanti PK, Jin H, Cui J, Li A, Zeng D, Rath NP, Flores H, Perlmutter JS, Parsons SM, Tu Z. Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. J Med Chem. 2013 Aug 8;56(15):6216-33.
  • Sun J, Cairns NJ, Perlmutter JS, Mach RH, Xu J. Regulation of dopamine D3 receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. 2013 Jun 1;248C:112-126.
  • Karimi M, Tian L, Brown CA, Flores HP, Loftin SK, Videen TO, Moerlein SM, Perlmutter JS. Validation of nigrostriatal positron emission tomography measures: critical limits. Ann Neurol. 2013 Mar;73(3):390-6.
  • Ushe M, Perlmutter JS. Sex, drugs and Parkinson’s disease. Brain. 2013 Feb;136(Pt 2):371-3.

Dr. Perlmutter is a fellow of the American Academy of Neurology, the International Society of Cerebral Blood Flow & Metabolism and the Parkinson’s Study Group, the Huntington’s Study Group, the Dystonia Study Group and is a Fellow of the American Neurological Association . He serves as Director of Medical Advisory Committee of the Missouri Chapter of the Dystonia Medical Research Foundation, as Medical Director of the Parkinson’s Disease Information and Referral Center, and as a member of the advisory board of the the St. Louis Chapter of the American Parkinson’s Disease Association.

In 1992 and 1998, Dr. Perlmutter won the Eliasson Award for Outstanding Professor of Neurology, and in 1998 he won the Outstanding Young Alumni Physician’s Award from the University of MO-Columbia.

LICENSURE: Diplomate, NBME; MO Board of the Healing Arts; Diplomate, American Board of Neurology & Psychiatry.