Gregory F Wu, MD, PhD

Assistant Professor of Neurology

Phone314-362-3293

Emailwug@neuro.wustl.edu

Board Certifications

  • Psychiatry and Neurology - Certified

Publications

  • Shin S, Walz KA, Archambault AS, Sim J, Bollman BP, Koenigsknecht-Talboo J, Cross AH, Holtzman DM, Wu GF. Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis. J Neuroimmunol. 2014 Mar 29. pii: S0165-5728(14)00074-5.
  • Archambault AS, Carrero JA, Barnett LG, McGee NG, Sim J, Wright JO, Raabe T, Chen P, Ding H, Allenspach EJ, Dragatsis I, Laufer TM, Wu GF. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol. 2013 Jul 15;191(2):545-50.
  • Wu GF, Alvarez E. The immunopathophysiology of multiple sclerosis. Neurol Clin. 2011 May;29(2):257-78.
  • Wu, G.F., Shindler, K.S., Allenspach, E.J., Stephen, T.L., Thomas, H.L., Mikesell, R.J., Cross, A.H., and Laufer, T.M. Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity. J Autoimmun. 2011 February; 36 (1):56-64.
  • Cross, A.H. and Wu, G.F. Multiple sclerosis: oligoclonal bands still yield clues about multiple sclerosis. Nat Rev Neurol. 2010 Nov; 6 (11):588-9. Commentary.
  • Shaffer, M.H., Huang, Y., Corbo, E., Wu, G.F., Velez, M. Choi, J.K., Saotome, I., Cannon, J.L., McClatchey, A.I., Sperling, A.I., Maltzman, J.S., Oliver, P.M., Bhandoola, A. Laufer, T.M., and Burkhardt J.K. Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One. 2010 August 27; 5 (8): e12404.
  • Laufer T. M. and Wu, G.F. Treating MS: getting to know the two birds in the bush. J Clin Invest. 2009 July; 119 (7): 1852. Commentary.
  • Wilson, E.H., Harris, T.H., Mrass, P., John, B., Tait, E.D., Wu, G.F., Pepper, M., Wherry, E.J., Dzierzinkski, F., Roos, D., Haydon, P.G., Laufer, T.M., Weninger, W., Hunter, C.A. Behavior of parasite specific effector CD8+ T cells in the CNS and visualization of a kinesis-associated system of reticular fibers during infection Immunity. 2009 Feb 20; 30 (2): 300-11.
  • Wu, G.F., Schwartz, E.D., Lei, T., Souza, A., Mishra, S., Jacobs, D.A, Markowitz, C.E., Galetta, S.L., Nano-Schiavi, M.L., Desiderio, L.M., Cutter, G.R., Udupa, J.K. and Balcer, L.J. Relation of Vision to Global and Regional Brain MRI in Multiple Sclerosis. Neurology 69(23):2128-2135, December, 2007.
  • Elman, L.B., Houghton, D.J., Wu, G.F., Hurtig, H.I., Markowitz, C.E., and McCluskey, L. Palliative Care in Amyotrophic Lateral Sclerosis, Parkinson’s Disease, and Multiple Sclerosis. J Palliat Med. 10(2):433-457, April, 2007.
  • Bataller L., Kleopa K.A., Wu G.F., Rossi J.E., Rosenfeld M.R., Dalmau J. Autoimmune Limbic Encephalitis in 39 Patients: Immunophenotypes and Outcomes. J Neurol Neurosurg Psychiatry. September 2006.
  • Taylor, R.A., Wu, G.F., Hurst, R.W., Kasner, S.E. and Cucchiara, B.L. Transient Global Amnesia Heralding Basilar Artery Thrombosis. Clin. Neurol. Neurosurg. 108: 60-62, December, 2005.
  • Wu, G.F. and Balcer, L.J. Endocrine and metabolic deficiency. Ophthalmol Clin North Am. 17 (3): 427-34, September, 2004.
  • Sheth, K.N., Wu, G.F., Messe, S.R., Wolf, R.L. and Kasner, S.E. Dialysis Disequilibrium: Another Reversible Posterior Leukoencephalopathy Syndrome? Clin. Neurol. Neurosurg. 105: 249-252, August, 2003.

Dr. Wu was born and raised in Iowa. He attended college at Washington University in St. Louis before returning to Iowa to obtain his MD and PhD degrees. He performed post-graduate training in New York and Philadelphia. The Wu lab is dedicated to understanding what triggers the development of immune responses in the central nervous system during health and disease. In particular the lab is focused on dendritic cells, a special class of immune cells capable of initiating a wide spectrum of lymphocyte responses. Several lines of evidence suggest that dendritic cells are critical during the pathogenesis of central nervous system inflammation. This is particularly relevant to diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Ongoing research is aimed at understanding how dendritic cells are capable of initiating autoimmune reactions targeting the brain and spinal cord.