Glenn Lopate, MD

Professor of Neurology

Phone314-362-6981

Fax314-362-3752

Emaillopateg@neuro.wustl.edu

Board Certifications

  • Electrodiagnostic Medicine - Certified
  • Neurology - Certified

Related Links

Clinical Interests

Dr. Lopate was born in Cleveland, Ohio in 1961. He graduated from high school in 1979 before going to Colorado State University to obtain his Bachelor of Science degree in Zoology, graduating cum laude and being selected to join the Phi Beta Kappa society. After graduation in 1983, he went to The Ohio State University School of Medicine. He graduated from medical school in 1987 and did a one-year internship at Riverside Methodist Hospital in Columbus, Ohio. He came to Barnes Hospital for neurology training in 1988, and stayed on at Washington University after completing his residency in 1991. Dr. Lopate completed a three-year fellowship in Neuromuscular Disease in 1994 and then became an Instructor in Neurology. He was promoted to Assistant Professor in 1999, to Associate Professor in 2004 and Professor in 2015. He is board certified in Psychiatry and Neurology, Electrodiagnostic Medicine and Neuromuscular Disease. He is a member of the American Academy of Neurology and the American Association of Electrodiagnostic Medicine.

Publications

  • Lopate G, Streif E, Harms M, Weihl C, Pestronk A. Cramps and small-fiber neuropathy. Muscle Nerve. 2013 Aug;48(2):252-5.
  • Harms MB, Sommerville RB, Allred P, Bell S, Ma D, Cooper P, Lopate G, Pestronk A, Weihl CC, Baloh RH. Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Ann Neurol. 2012 Mar;71(3):407-16.
  • Lopate G, Pestronk A. Inflammatory demyelinating neuropathies. Curr Treat Options Neurol. 2011 Apr;13(2):131-42.
  • Lopate G, Baloh RH, Al-Lozi MT, Miller TM, Fernandes Filho JA, Ni O, Leston A, Florence J, Schierbecker J, Allred P. Familial ALS with extreme phenotypic variability due to the I113T SOD1 mutation. Amyotroph Lateral Scler. 2010;11(1-2):232-6.
  • Weihl CC, Lopate G. Motor neuron disease associated with copper deficiency. Muscle Nerve. 2006 Dec;34(6):789-93.
  • Pestronk A, Kos K, Lopate G, Al-Lozi MT. Brachio-cervical inflammatory myopathies: clinical, immune, and myopathologic features. Arthritis Rheum. 2006 May;54(5):1687-96.
  • Lopate G, Pestronk A, Al-Lozi M, Lynch T, Florence J, Miller T, Levine T, Rampy T, Beson B, Ramneantu I. Peripheral neuropathy in an outpatient cohort of patients with Sjögren’s syndrome. Muscle Nerve. 2006 May;33(5):672-6.
  • Strom RG, Derdeyn CP, Moran CJ, Cross DT, Esper GJ, Mazumdar A, Al-Lozi M, Lopate G, Pestronk A. Frequency of spinal arteriovenous malformations in patients with unexplained myelopathy. Neurology. 2006 Mar 28;66(6):928-31.
  • Lopate G, Pestronk A, Evans S, Li L, Clifford D. Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy. Neurology. 2005 May 10;64(9):1632-4.
  • Lopate G, Pestronk A, Al-Lozi M. Treatment of chronic inflammatory demyelinating polyneuropathy with high-dose intermittent intravenous methylprednisolone. Arch Neurol. 2005 Feb;62(2):249-54.
  • Pestronk A, Florence J, Levine T, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M. Sensory exam with a quantitative tuning fork: rapid, sensitive and predictive of SNAP amplitude. Neurology. 2004 Feb 10;62(3):461-4.
  • Racette BA, Lopate G, Good L, Sagitto S, Perlmutter JS. Ptosis as a remote effect of therapeutic botulinum toxin B injection. Neurology. 2002 Nov 12;59(9):1445-7.
  • Miller T, Al-Lozi MT, Lopate G, Pestronk A. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry. 2002 Oct;73(4):420-8.
  • Lopate G, Choksi R, Pestronk A. Severe sensory ataxia and demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1A antibodies. Muscle Nerve. 2002 Jun;25(6):828-36.
  • Lopate G, Kornberg AJ, Yue J, Choksi R, Pestronk A. Anti-myelin associated glycoprotein antibodies: variability in patterns of IgM binding to peripheral nerve. J Neurol Sci. 2001 Jul 15;188(1-2):67-72.

Dr. Glenn Lopate is a Professor of Neurology in the Neuromuscular Disease Division at Washington University School of Medicine. He sees patients in the Neuromuscular Disease clinic and the Washington University Electrodiagnostic Laboratory and is involved in clinical research of neuromuscular disease. He is the head of the skin pathology section of the Neuromuscular Disease Clinical Laboratory. His primary research focus has mostly been to better understand the pathogenesis of neuropathies, including immune mediated, hereditary and small fiber neuropathies. Currently, the emphasis in his laboratory is to better understand the pathology, pathophysiology and ultimately treatment for patients with small fiber neuropathy.

The skin pathology section of the Neuromuscular Disease Laboratory opened in 2008. The laboratory uses conventional PGP 9.5 staining methods on skin samples, but has also developed techniques to stain small nerve fibers in muscle tissue. In this way measurements of small nerve fiber loss in non-linear tissues can be performed. Using these techniques, the laboratory has shown that there is a reduced number of small nerve fibers not only in skin, but also in muscle in patients with small fiber neuropathy.

In addition to small fiber neuropathy, Dr. Lopate has an interest in characterization and treatment of immune mediated neuropathies. He has helped to report on outpatient cohorts of patients with Sjogren’s syndrome and Waldenstrom’s macroglobulinemia to better define the more common neuropathy syndromes in these patient populations. He has also been involved in treatment trials of multifocal motor neuropathy and familial amyloid polyneuropathy as well as helping to define optimal corticosteroid regimens in patients with chronic inflammatory demyelinating polyneuropathy.

He has been a member of the Washington University local IRB since 2004. He has chaired the AANEM Monograph/Issues and Opinions Committee since 2013 and serves on the AANEM CME Advisory Committee. He has been the PI on treatment trials for multifocal motor neuropathy and currently for familial amyloid polyneuropathy