Erik Musiek, MD, PhD

Assistant Professor of Neurology

Phone314-286-2881

Board Certifications

  • Neurology - Certified

Related Links

Publications

  • Musiek ES, Fitzgerald GA. Molecular clocks in pharmacology. Handb Exp Pharmacol. 2013;(217):243-60.
  • Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec 2;123(12):5389-400.
  • Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA. Knitting up the raveled sleave of care. Sci Transl Med. 2013 Nov 20;5(212):212rv3.
  • Musiek ES, Schindler SE. Alzheimer disease: current concepts & future directions. Mo Med. 2013 Sep-Oct;110(5):395-400. Review.
  • Musiek ES, Holtzman DM. Origins of Alzheimer’s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Curr Opin Neurol. 2012 Dec;25(6):715-20.
  • Musiek ES, Saboury B, Mishra S, Chen Y, Reddin JS, Newberg AB, Udupa JK, Detre JA, Hofheinz F, Torigian D, Alavi A. Feasibility of estimation of brain volume and 2-deoxy-2-(18)F-fluoro-D-glucose metabolism using a novel automated image analysis method: application in Alzheimer’s disease. Hell J Nucl Med. 2012 Sep-Dec;15(3):190-6.
  • Musiek ES, Chen Y, Korczykowski M, Saboury B, Martinez PM, Reddin JS, Alavi A, Kimberg DY, Wolk DA, Julin P, Newberg AB, Arnold SE, Detre JA. Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer’s disease. Alzheimers Dement. 2012 Jan;8(1):51-9.
  • Chen Y, Wolk DA, Reddin JS, Korczykowski M, Martinez PM, Musiek ES, Newberg AB, Julin P, Arnold SE, Greenberg JH, Detre JA. Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease. Neurology. 2011 Nov 29;77(22):1977-85.
  • Brooks JD, Musiek ES, Koestner TR, Stankowski JN, Howard JR, Brunoldi EM, Porta A, Zanoni G, Vidari G, Morrow JD, Milne GL, McLaughlin B. The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation. J Neurochem. 2011 Nov;119(3):604-16.
  • Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B. p66(shc)’s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone. Autophagy. 2010 Oct;6(7):948-9.
  • Musiek ES, Anderson CT, Dahodwala NA, Pollard JR. Facial tic associated with lamotrigine in adults. Mov Disord. 2010 Jul 30;25(10):1512-3.
  • Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne G, McLaughlin B. Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning. J Neurosci. 2010 Apr 14;30(15):5242-52.
  • Zeiger SL, Musiek ES, Zanoni G, Vidari G, Morrow JD, Milne GJ, McLaughlin B. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Free Radic Biol Med. 2009 Nov 15;47(10):1422-31.
  • Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, Beal MF. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. PLoS One. 2009 Jun 1;4(6):e5757.
  • Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem. 2008 Jul 18;283(29):19927-35.

Dr. Musiek sees patients with cognitive disorders in Memory Disorder Clinic, participates in clinical studies through the Knight Alzheimer’s Disease Research Center (KADRC), and performs laboratory research on the molecular basis of age-related neurodegenerative diseases, particularly Alzheimer’s Disease, using animal and cellular models.