David B Clifford, MD

Head of the Section of Neuroinfectious Diseases—Adult Neurology; the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology




Board Certifications

  • Neurology
  • Psychiatry

Related Links


  • Listed in Best Doctors in America, 2005-2013 (Best Doctors, Inc.)


  • Biswas B, Spitznagel E, Collier AC, Gelman BB, McArthur JC, Morgello S, McCutchan JA, Clifford DB; the CHARTER Group. Characterizing HIV medication adherence for virologic success among individuals living with HIV/AIDS: Experience with the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort. J HIV AIDS Soc Serv. 2014 Jan 1;13(1):8-25.
  • Clifford DB, Ances BM. HIV-associated neurocognitive disorder. Lancet Infect Dis. 2013 Nov;13(11):976-86.
  • Hurth K, Tarawneh R, Ghoshal N, Benzinger TL, Clifford DB, Geschwind M, Morris JC, Galvin JE, Schmidt RE, Cairns NJ. Whipple’s Disease Masquerades as Dementia With Lewy Bodies. Alzheimer Dis Assoc Disord. 2013 Aug 29. [Epub ahead of print] No abstract available.
  • Clifford DB, Nath A, Cinque P, Brew BJ, Zivadinov R, Gorelik L, Zhao Z, Duda P. A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes. J Neurovirol. 2013 Aug;19(4):351-8.
  • Longbrake EE, Ances BM, Viets RB, Clifford DB. Susac syndrome in a patient with human immunodeficiency virus infection. J Neurovirol. 2013 Jun;19(3):270-3.
  • Solomon IH, Perrin RJ, Clifford DB, Ances BM. Tumefactive demyelination in a patient with human immunodeficiency virus. J Neurovirol. 2013 Jun;19(3):265-9.
  • Clifford DB, Simpson DM, Brown S, Moyle G, Brew BJ, Conway B, Tobias JK, Vanhove GF; NGX-4010 C119 Study Group. A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy. J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):126-33.
  • Ances BM, Benzinger TL, Christensen JJ, Thomas J, Venkat R, Teshome M, Aldea P, Fagan AM, Holtzman DM, Morris JC, Clifford DB. 11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder. Arch Neurol. 2012 Jan;69(1):72-7.
  • Overton ET, Kauwe JS, Paul R, Tashima K, Tate DF, Patel P, Carpenter CC, Patty D, Brooks JT, Clifford DB. Performances on the CogState and standard neuropsychological batteries among HIV patients without dementia. AIDS Behav. 2011 Nov;15(8):1902-9.
  • Clifford DB, Ances B, Costello C, Rosen-Schmidt S, Andersson M, Parks D, Perry A, Yerra R, Schmidt R, Alvarez E, Tyler KL. Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis. Arch Neurol. 2011 Sep;68(9):1156-64.
  • Mateen FJ, Muralidharan R, Carone M, van de Beek D, Harrison DM, Aksamit AJ, Gould MS, Clifford DB, Nath A. Progressive multifocal leukoencephalopathy in transplant recipients. Ann Neurol. 2011 Aug;70(2):305-22.
  • Ances BM, Christensen JJ, Teshome M, Taylor J, Xiong C, Aldea P, Fagan AM, Holtzman DM, Morris JC, Mintun MA, Clifford DB. Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study. Neurology. 2010 Jul 13;75(2):111-5.
  • Clifford DB, De Luca A, Simpson DM, Arendt G, Giovannoni G, Nath A. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol. 2010 Apr;9(4):438-46.
  • Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JS. CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease. Neurology. 2009 Dec 8;73(23):1982-7.
  • Clifford DB, Evans S, Yang Y, Acosta EP, Ribaudo H, Gulick RM; A5097s Study Team. Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s). HIV Clin Trials. 2009 Nov-Dec;10(6):343-55.

David Clifford is the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology and Professor of Medicine

He has assumed positions of leadership in the Medical School, including chairing the Executive Committee of the Faculty Council, faculty clinical representative to the Faculty Practice Plan, and serving on numerous committees.

Dr. Clifford has served as President of the medical staff of St. Louis ConnectCare, the corporation providing indigent health care in the St. Louis region and as Medical Director of Neurology for Barnes Jewish Hospital.

On a national basis, Dr. Clifford has chaired the Neurology Section of the AIDS Clinical Trials Group, served on the Scientific Program Committees for the American Academy of Neurology and for the Conference on Retroviruses and Opportunistic Infections, as a Counsellor for the American Neurological Association, Chairs the External Advisory Committee for the National NeuroAIDS Tissue Consortium and is a member of the American Federation for AIDS Research Scientific Advisory Board. He sits on the editorial boards of Journal of NeuroVirology and NeuroAIDS and is a frequent ad hoc reviewer for the major neurologic journals. He is listed in “Best Doctors in the U.S.”.

Dr. Clifford is the Principal Investigator of the NINDS supported Neurologic AIDS Research Consortium (NARC), a national group including over 20 medical centers that organizes and supports clinical trials for HIV neurologic complications. In addition, Dr.Clifford has participated in pharmacologic investigations in Parkinson’s Disease and multiple sclerosis. He is also the Principal Investigator for the Washington University AIDS Clinical Trials Unit organized to lead translational research relevant to HIV/AIDS.

Dr. Clifford has a broad interest in neuropharmacology. Development of more successful medical management of neurological disease has been his clinical focus, and has included participation in studies of epilepsy, Parkinson’s disease, multiple sclerosis, and virtually all neurologic complications of HIV. His present focus is on developing optimal treatments for neurologic complications of HIV including HIV-associated dementia, painful peripheral neuropathies in HIV, progressive multifocal leukoencephalopathy, cryptococcal meningitis, toxoplasma encephalitis, primary CNS lymphoma, cytomegalovirus encephalitis/radiculomyelitis, and HIV myelopathy. Dr. Clifford leads a nationwide clinical research group, the Neurologic AIDS Research Consortium, funded by NINDS of the National Institute of Health, whose specific mission is to pursue better treatments for HIV associated neurologic complications. He is also Principal Investigator for the Washington University AIDS Clinical Trials Unit. He is working in international studies, particularly cooperating with medical schools of Ethiopia to further diagnosis and treatment of HIV in that country.