David L Brody, MD, PhD

Associate Professor of Neurology

Phone314-362-4503

Fax314-362-2244

Emailbrodyd@neuro.wustl.edu

Board Certifications

  • Neurology

Research Interests

Research in Brody laboratory and collaborative group is focused on the development of novel therapeutic and diagnostic strategies for traumatic brain injury (TBI) and Alzheimer’s disease. TBI is a major cause of morbidity and mortality worldwide, a major risk factor for the development of Alzheimer’s Disease, and the single leading cause of permanent disability in people under age 45 in the United States. The laboratory is funded by grants from the NIH, Department of Defense, and Bright Focus Foundation. He was the recipient of the Washington University School of Medicine Distinguished Investigator Award in 2012.

Related Links

Recognition

  • National Football League Player Care Plan: Washington University Site Leader, 2010
  • Hope Center for Neurological Disorders Prize, Postdoctoral category, Washington University, 2005
  • Invited Speaker, Inaugural Postdoctoral Symposium, Washington University,2005
  • Burroughs Wellcome Career Award in the Biomedical Sciences, 2005-present
  • NIH Mentored Clinical Scientist Development Award (K08), NINDS, 2004-present
  • The Leonard Berg Prize for Research Conducted During Residency, Washington University, 2004
  • Medical Student Teaching Award, Washington University, 2004
  • Hans Prohaska Young Investigator Award, Johns Hopkins School of Medicine, 2000
  • NIH Medical Scientist Training Program Fellowship, 1992-2000

Publications

  • Macdonald CL, Johnson AM, Nelson EC, Werner NJ, Fang R, Flaherty SF, Brody DL. Functional Status after Blast-Plus-Impact Complex Concussive Traumatic Brain Injury in Evacuated United States Military Personnel. J Neurotrauma. 2014 Feb 10. [Epub ahead of print]
  • Han K, Mac Donald CL, Johnson AM, Barnes Y, Wierzechowski L, Zonies D, Oh J, Flaherty S, Fang R, Raichle ME, Brody DL. Disrupted modular organization of resting-state cortical functional connectivity in U.S. military personnel following concussive ‘mild’ blast-related traumatic brain injury. Neuroimage. 2014 Jan 1;84:76-96.
  • Mac Donald C, Johnson A, Cooper D, Malone T, Sorrell J, Shimony J, Parsons M, Snyder A, Raichle M, Fang R, Flaherty S, Russell M, Brody DL. Cerebellar white matter abnormalities following primary blast injury in US military personnel. PLoS One. 2013;8(2):e55823.
  • Klemenhagen KC, O’Brien SP, Brody DL. Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in mice. PLoS One. 2013 Sep 18;8(9):e74510.
  • Guo D, Zeng L, Brody DL, Wong M. Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury. PLoS One. 2013 May 14;8(5):e64078.
  • Bennett RE, Esparza TJ, Lewis HA, Kim E, Mac Donald CL, Sullivan PM, Brody DL. Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. J Neuropathol Exp Neurol. 2013 May;72(5):396-403.
  • Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol. 2013 Jan;73(1):104-19.
  • Bennett RE, Mac Donald CL, Brody DL. Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury. Neurosci Lett. 2012 Apr 4;513(2):160-5.
  • Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol. 2013 Jan;73(1):104-19.
  • Bennett RE, Mac Donald CL, Brody DL. Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury. Neurosci Lett. 2012 Apr 4;513(2):160-5.
  • Tran HT, Sanchez L, Brody DL. Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice. J Neuropathol Exp Neurol. 2012 Feb;71(2):116-29.
  • Mac Donald CL, Johnson AM, Cooper D, Nelson EC, Werner NJ, Shimony JS, Snyder AZ, Raichle ME, Witherow JR, Fang R, Flaherty SF, Brody DL. Detection of blast-related traumatic brain injury in U.S. military personnel. N Engl J Med. 2011 Jun 2;364(22):2091-100.
  • Marion DW, Curley KC, Schwab K, Hicks RR; mTBI Diagnostics Workgroup. Proceedings of the military mTBI Diagnostics Workshop, St. Pete Beach, August 2010. J Neurotrauma. 2011 Apr;28(4):517-26.
  • Magnoni S, Brody DL. New perspectives on amyloid-beta dynamics after acute brain injury: moving between experimental approaches and studies in the human brain. Arch Neurol. 2010 Sep;67(9):1068-73.

Dr. Brody is a Full Professor in the Department of Neurology. He treats patients with subacute and chronic sequelae of traumatic brain injury in the Traumatic Brain Injury Clinic located at Center for Advanced Medicine.

He is the Washington University site director for the National Football League Neurological player care program.

His clinical monograph entitled Concussion Care Manual: A Practical Guide was published by Oxford University Press in 2014.

He has advised the US Army Vice Chief of Staff and assisted the Medical Advisor to the Chairman of the Joint Chiefs of Staff.

He is a member of the Editorial Board of the Journal of Neurotrauma and Acta Neuropathologica

He is a permanent member of the NIH Acute Neural Injury and Epilepsy study section.

He is the co-organizer of the Axon Injury and Repair Research Interest Group (part of the Hope Center for Neurological Disorders) and is a member of the Division of Biology and Biomedical Sciences in the Neurosciences Program.

Dr. Brody was born and raised in San Diego, California. He attended La Jolla High School, and completed undergraduate studies in Biological Sciences at Stanford University in 1992. His undergraduate research project involved computational modeling of parallel distributed neural networks in the laboratory of Dr. William Kristan at the University of California at San Diego.