Christopher D Smyser, MD

Assistant Professor of Neurology



Board Certifications

  • Pediatric Neurology - Certified


  • Steven M. Rothman Award for Outstanding Teaching by a Child Neurology Resident, Department of Neurology, Washington University School of Medicine, 2008


  • Al-Kateb H, Khanna G, Filges I, Hauser N, Grange DK, Shen J, Smyser CD, Kulkarni S, Shinawi M. Scoliosis and vertebral anomalies: Additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement. Am J Med Genet A. 2014 May;164(5):1118-26.
  • Estep ME, Smyser CD, Anderson PJ, Ortinau CM, Wallendorf M, Katzman CS, Doyle LW, Thompson DK, Neil JJ, Inder TE, Shimony JS. Diffusion tractography and neuromotor outcome in very preterm children with white matter abnormalities. Pediatr Res. 2014 Apr 8.
  • Pineda RG, Neil J, Dierker D, Smyser CD, Wallendorf M, Kidokoro H, Reynolds LC, Walker S, Rogers C, Mathur AM, Van Essen DC, Inder T. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014 Jan;164(1):52-60.e2.
  • Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol. 2013 Oct;34(10):1866-72.
  • Smyser CD, Snyder AZ, Shimony JS, Blazey TM, Inder TE, Neil JJ. Effects of white matter injury on resting state fMRI measures in prematurely born infants. PLoS One. 2013 Jul 9;8(7):e68098.
  • McDonell LM, Mirzaa GM, Alcantara D, Schwartzentruber J, Carter MT, Lee LJ, Clericuzio CL, Graham JM Jr, Morris-Rosendahl DJ, Polster T, Acsadi G, Townshend S, Williams S, Halbert A, Isidor B, David A, Smyser CD, Paciorkowski AR, Willing M, Woulfe J, Das S, Beaulieu CL, Marcadier J; FORGE Canada Consortium, Geraghty MT, Frey BJ, Majewski J, Bulman DE, Dobyns WB, O’Driscoll M, Boycott KM. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nat Genet. 2013 May;45(5):556-62.
  • Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS. Congenital Lymphocytic Choriomeningitis Virus: When to Consider the Diagnosis. J Child Neurol. 2013 May 10. [Epub ahead of print]
  • Smyser CD, Kidokoro H, Inder TE. Magnetic resonance imaging of the brain at term equivalent age in extremely premature neonates: to scan or not to scan? J Paediatr Child Health. 2012 Sep;48(9):794-800.
  • Mirzaa GM, Paciorkowski AR, Smyser CD, Willing MC, Lind AC, Dobyns WB. The microcephaly-capillary malformation syndrome. Am J Med Genet A. 2011 Sep;155A(9):2080-7.
  • Smyser CD, Snyder AZ, Neil JJ. Functional connectivity MRI in infants: exploration of the functional organization of the developing brain. Neuroimage. 2011 Jun 1;56(3):1437-52.
  • Smyser CD, Inder TE, Shimony JS, Hill JE, Degnan AJ, Snyder AZ, Neil JJ. Longitudinal analysis of neural network development in preterm infants. Cereb Cortex. 2010 Dec;20(12):2852-62
  • Smyser CD, Grabowski TJ, Rainville P, Bechara A, Razavi M, Mehta S, Eaton BL, Bolinger L. Measurement, time-stamping, and analysis of electrodermal activity in fMRI. Proceedings of the International Society of Optical Engineering (SPIE) 4683: 470-475, 2002.
  • Smyser CD, Grabowski TJ, Frank RJ, Haller J, Bolinger L. A time-aware architecture for parametric analysis of fMRI data. Magnetic Resonance in Medicine 45(2): 289-298, 2001.

Dr. Smyser’s clinical efforts are focused upon the development of the multidisciplinary Neonatal Neurology Clinical Service which is designed to provide optimal neurological care for infants at risk for poor neurodevelopmental outcomes beginning during their initial hospitalization and continuing following discharge. This Service is comprised of two main components – a Neonatal Neurology Consultation Service designed to evaluate and direct inpatient neurological care for NICU patients, and a Neonatal Neurology Follow-up Clinic designed to evaluate and manage patients with neurological concerns in the outpatient setting.

Dr. Smyser is a member of the Washington University Neonatal Developmental Research (WUNDER) group. His research is focused upon development and optimization of the tools necessary to utilize functional connectivity MRI (fcMRI) to investigate neural network development in preterm and term infants as part of an ongoing study examining cerebral abnormalities associated with neurodevelopmental impairment in prematurely born children.