Chihiro Sato, Ph.D

Research Instructor in Neurology

Related Links


  • Ph.D. in Pharmaceutical Sciences: University of Tokyo, Japan (2008)


  • Charleston Conference for Alzheimer’s Disease (CCAD) attendee 2016
  • Invited speaker: Monitoring Molecules in Neuroscience (MMIN) 2016

Research Interests

Tau kinetics, Stable Isotope Labeling Kinetics, Alzheimer’s Disease, Tauopathies


Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem 23;280(51):41967-75, 2005. PMID:16234244

Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma secretase probed by the accessibility of substituted cysteines. J Neurosci 26:12081-12088, 2006. PMID: 17108181

Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 7;52(5):831-43, 2006. PMID:17145504

Sato C, Iwatsubo T. Focusing on beta-amyloid: report of the 35th Annual Meeting of the Society for Neuroscience. Amyloid. 13(2):114-6, 2006.   PMID:16911967

Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J Biol Chem. 26;281(21):14670-6, 2006.  PMID:16569643

Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. J Biol Chem 282:12388-12396, 2007. PMID: 17329245

Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of Presenilin 1 are involved in the formation of the catalytic pore of the γ−secretase. J Neurosci, 28:6264-6271, 2008. PMID: 18550769

Hass MR, Sato C, Kopan R, Zhao G. Presenilin: RIP and beyond (Review). Semin Cell Dev Biol. 20:201-210, 2009. PMID: 19073272. PMCID: PMC2693421

Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ−secretase. J Neurosci, 30:15943-50, 2010. PMID: 21106832

Liu J, Sato C, Cerletti M, Wagers A. Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation. Current Topics in Developmental Biology, 92 (chapter 12), 2010. PMID: 20816402

Sato C, Turkoz M, Dearborn JT, Wozniak DF, Kopan R, Hass MR. Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. Plos One 7(10): e48180, 2012. PMID: 23110206. PMCID: PMC3482205

Sato C, Zhao G, Ilagan MX. An overview of Notch signaling in adult tissue renewal and maintenance. (Review) Current Alzheimer Research. 9:227-240, 2012. PMID: 21605032