Carla M Yuede, Ph.D

Assistant Professor of Neurology

Phone314-362-9001

Emailyuedec@wustl.edu

Education

  • Postdoctoral Fellow, Neuroscience: Washington University School of Medicine, St. Louis, MO (2011)
  • Doctor of Philosophy, Behavioral Neuroscience: University of Missouri, St. Louis, MO (2006)
  • Bachelor of Science, Psychology/Biomedical Science: Missouri State University (2000)

Research Interests

The rapidly increasing incidence of Alzheimer’s disease (AD) in our society highlights the necessity for a more complete understanding of its development and progression so effective treatments can be designed. My approach to AD research involves combining techniques to find novel ways to uncover aspects about the disease process. Using an interdisciplinary approach to study biological processes from different angles gives us a more complete picture and will facilitate strategies to minimize or eliminate the symptoms of the disease.

Accumulation of toxic Aβ in the brain is believed to be the primary cause of the cognitive and behavioral symptoms of AD. Synaptic activity is responsible for at least 70% of Aβ production in the brain, however the mechanisms underlying this relationship are not fully understood. Our research focuses on the factors influencing brain Aβ dynamics in mouse models of AD, particularly in relation to synaptic activity. We have developed novel micro-immunoelectrodes to measure Aβ with increased temporal resolution in the brains of living mice. Like the in vivo microdialysis technique developed in our lab, these methods provide unique routes to address issues concerning how Aβ levels change over time and with different conditions. Using these techniques we can monitor Aβ kinetics in the context of aging, behavior, drug treatment and genetic manipulation to identify mechanisms governing the relationship between synaptic activity and Aβ production in vivo. Our long-term goal is to understand the pathways and risk factors involved in Aβ generation and accumulation in the brain, with the hope of identifying effective therapeutic targets.

As part of the Animal Behavior Core at Washington University, I am involved in helping investigators design and interpret behavioral function in many animal models of disease. Coming from a behavioral neuroscience background, I have extensive experience with different animal models and tests of behavioral function, specifically analyzing ways in which cognitive function can be altered by manipulating brain function through neurotransmitter systems using genetics or pharmacology. This approach gives us opportunities to understand genetic involvement in behavioral function and to screen treatments that will influence the symptoms of the disease under investigation. My research interests involve behavioral phenotyping of new genetic models, as well as evaluating functional effects of specific treatment strategies on diverse models of neurological disorders.

Publications

  1. Yuede CM, Lee H, Restivo JL, Davis TA, Hettinger JC, Wallace CE, Young KL, Hayne MR, Bu G, Li C-Z, Cirrito JR (2016) Rapid measurement of Aβ using micro-immunoelectrodes in vivo reveals biphasic clearance kinetics in an Alzheimer’s mouse model. Journal of Experimental Medicine 213(5):677-685. PMID: 27069115
  2. Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, Cirrito JR, Yuede CM, Zimmerman SD, Timson BF (2016) A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer’s disease. Neurobiol Dis Jan;85:218-24 PMID: 26563933
  3. Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, Yuede CM, Galimberti D, Olivecrona G, Klein RS, Cross AH, Otero K, Piccio L (2015) TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathol Mar;129(3):429 PMID: 25631124
  4. Idol RA, Wozniak DF, Fujiwara H, Yuede CM, Ory DS, Kornfeld S, Vogel P (2014) Neurologic Abnormalities in Mouse Models of the Lysosomal Storage Disorders Mucolipidosis II and Mucolipidosis III γ. PLoS One Oct 14;9(10) PMID: 25314316
  5. Yuede CM, Olney JW, Creeley CE (2013) Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine. Brain Sci Jul 30;3(3):1128-52 PMID: 24734165
  6. Wozniak DF, Diggs-Andrews KA, Conyers S, Yuede CM, Dearborn JT, Brown JA, Tokuda K, Izumi Y, Zorumski CF, Gutmann DH (2013) Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice. PLoS One 2013 Jun 10;8(6):e66024. PMID: 23762458
  7. Meng L, Lu L, Murphy KM, Yuede CM, Cheverud JM, Csernansky JG, Dong H (2011) Neuroanatomic and behavioral traits for autistic disorders in age-specific restricted index selection mice. Neuroscience Aug 25;189:215-22 PMID: 21624435
  8. Brown JA, Emnett RJ, White CR, Yuede CM, Conyers SB, O’Malley KL, Wozniak DF, Gutmann DH (2010) Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice. Hum Mol Genet Nov 15;19(22):4515-28. PMID: 20826448
  9. Yuede CM, Wozniak DF, Creeley CE, Taylor GT, Olney JW, Farber NB (2010) Behavioral consequences of NMDA antagonist-induced neuroapoptosis in the infant mouse brain. PLoS One Jun 29;5(6):e11374. PMID: 20613880
  10. Dong H, Yuede CM, Coughlan CA, Murphy KM, Csernansky JG (2009) Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer’s disease. Brain Research Dec 15;1303:169-78. PMID: 19799879
  11. Yuede CM, Zimmerman SD, Dong H, Kling MJ, Bero AW, Holtzman DM, Timson BF, Csernansky JG (2009) Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer’s disease. Neurobiol Dis Sep;35(3):426-32. PMID: 19524672
  12. Dong H, Yuede CM, Yoo HS, Martin MV, Deal C, Mace AG, Csernansky JG (2008) Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice. Neuroscience Jul 31;155(1):154-63. PMID: 18571864
  1. Dong H, Yuede CM, Coughlan C, Lewis B, Csernansky JG (2008) Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer’s disease. Neuropsychopharmacology Dec;33(13):3226-36. PMID: 18418360
  2. Yuede CM, Dong H, Csernansky JG (2007) Anti-dementia drugs and hippocampal-dependent memory in rodents. Behav Pharmacol Sep;18(5-6):347-63. Review. PMID: 17762506
  3. Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV (2007) Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury. J Neurotrauma Apr;24(4):657-73. PMID: 17439349
  4. Izumi Y, Kitabayashi R, Funatsu M, Izumi M, Yuede C, Hartman RE, Wozniak DF, Zorumski CF (2005) A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. Neuroscience Sep 21;136(1):269-79. PMID: 16181739
  5. Taylor GT, Yuede CM (2005) Behaviorally timid rats respond differentially to conventional and atypical neuroleptics. Pharmacol Biochem Behav Jul;81(3):478-84 PMID: 15913748

Invited publications:

Yuede CM, Taylor GT. Biological Bases of Shyness: Animal models of Social Phobia. In Social Phobia:

Eitology, Diagnosis and Treatment.  Nova Science Publishers. 2008 New York, NY