Andrew Sauerbeck, PhD

Education

  • Ph.D - Anatomy&Neurobiology: University of Kentucky, Lexington, KY (2010)

Research Interests

Dr. Sauerbeck’s research has focused on using pre-clinical rodent models to characterize the pathophysiology of CNS trauma in order to better understand, diagnose, and treat its effects in patients. He is currently focused on better understanding the range of injuries at the severe end of mild traumatic brain injury spectrum to moderate brain injury. These injuries often produce no clinically-detectable brain lesions, however, they can lead to persistent neurologic impairment. This leaves a critical unmet need for novel diagnostic and treatment modalities. Recent work by Dr. Sauerbeck has led to the development of a novel clinically relevant mouse model that produces both the biomechanical forces needed to model human brain injury in a mouse and the underlying structural damage most commonly seen in humans. This model generates an injury matching what is clinically known as complicated-mild to moderate traumatic brain injury. These subclasses of brain injury lead to persistent psychological and psychiatric impairment in humans. Ongoing work is focused on elucidating the underlying injury mechanisms after the brain injury in order to develop diagnostic and therapeutic interventions for use in patients.

Publications

A.Sauerbeck, J. Gao, R. Readnower,  Liu M,  J. Pauly, G. Bing, P.G. Sullivan. Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Exp Neurol. 2010 Oct 20. PMID: 20965168

Readnower , A. Sauerbeck ,P.G. Sullivan. Mitochondria, Amyloid β, and Alzheimer’s Disease. Int J Alzheimers Dis. 2011 Mar 22;2011:104545 PMID: 21547208

A.Sauerbeck, J Pandya, I Singh , K Bittman , R Readnower , G Bing , P.G. Sullivan. Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system Journal of Neuroscience Methods 2011 May 15;198(1):36-43. PMID: 21402103

A.Sauerbeck; RL Hunter,  G Bing , P.G. Sullivan. Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and             mitochondrial    deficits. Exp Neurol. 2012 Mar;234(1):85-94. PMID: 22201550

A.Sauerbeck , DL Schonber, JL Law, DM McTigue Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats. Exp Neurol. 2013 May 24;248C:53-61. PMID: 23712107

Mandrekar-Colucci , A. Sauerbeck, P.G. Popovich, D.M. McTigue. PPAR agonists as therapeutics for CNS trauma and neurological diseases. ASN neuro. 2013; 5(5):e00129. PMID: 24215544

A.Sauerbeck , DM McTigue. Spinal cord injury causes chronic liver pathology in rats. Journal of Neurotrauma. 2015 Feb 1;32(3):159-69. PMID: 25036371