Allyson R Zazulia, MD
Professor of Neurology
- Associate Professor, Radiology
- Vascular Neurology - Certified
- Neurology - Certified
- Listed in Best Doctors in America, 2005-2013 (Best Doctors, Inc.)
- Listed in America’s Top Doctors, 2005-2012 (Castle Connolly Medical Ltd.)
Stroke, intracerebral hemorrhage, cerebrovascular disease
Dr. Zazulia is a member of the Washington University Center for Stroke and Cerebrovascular Disease and the Barnes-Jewish Hospital Stroke Team and treats patients with stroke at Barnes-Jewish Hospital.
Diringer MN, Edwards DF, Zazulia AR (1998) Hydrocephalus: a previously unrecognized predictor of poor outcome from intracerebral hemorrhage. Stroke, 29:1352-1357.
Zazulia AR, Diringer MN, Derdeyn CP, Powers WJ (1999) Progression of mass effect after intracerebral hemorrhage. Stroke, 30:1167-1173.
Edwards DF, Hollingsworth H, Zazulia AR, Diringer MN (1999) Artificial neural networks improve the prediction of mortality in intracerebral hemorrhage. Neurology, 53:351-357.
Diringer MN, Yundt K, Videen TO, Adams RE, Zazulia AR, Deibert EM, Aiyagari V, Dacey RG, Grubb RL, Powers WJ (1999) No reduction in cerebral metabolism as a result of early moderate hyperventilation following severe traumatic brain injury. J Neurosurgery, 92:7-13.
Zazulia AR, Diringer MN, Videen TO, Adams RE, Yundt K, Aiyagari V, Grubb RL, Powers WJ (2001) Hypoperfusion Without Ischemia Surrounding Acute Intracerebral Hemorrhage. J Cerebral Blood Flow Metab, 21:804-810.
Powers WJ, Zazulia AR, Videen TO, Adams, RE, Yundt K, Aiyagari V, Grubb RL, Diringer MN (2001) Autoregulation of cerebral blood flow surrounding acute (5-22 hours) intracerebral hemorrhage. Neurology,57:18-24.
Videen TO, Zazulia AR, Manno EM, Derdeyn CP, Adams RE, Diringer MN, Powers WJ (2001) Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke. Neurology, 57:2120-2122.
Diringer MN, Videen TO, Yundt K, Zazulia AR, Aiyagari V, Dacey RG, Grubb RL, Powers WJ (2002) Regional cerebrovascular and metabolic effects of hyperventilation following severe traumatic brain injury. J Neurosurgery, 96:103-108.
Powers WJ, Zazulia AR (2003) The use of positron emission tomography in cerebrovascular disease. Neuroimaging Clinics of North America, 13:741-758.
Diringer MN, Zazulia AR (2004) Osmotic therapy: fact and fiction. Neurocritical Care, 1:219-234.
Aiyagari V, Guijar A, Zazulia AR, Diringer MN (2004) Hourly blood pressure monitoring after intravenous tissue plasminogen activator for ischemic stroke: Does everyone need it? Stroke, 35: 2326-30.
Zurasky J, Aiyagari V, Zazulia A, Shackleford A, Diringer M (2005) Early mortality following spontaneous intracerebral hemorrhage. Neurology, 64:725-7.
Jost SC, Diringer MN, Zazulia AR, Videen TO, Aiyagari V, Grubb RL, Powers WJ (2005) Normal saline bolus increases cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage. J Neurosurgery, 103:25-30.
Diringer MN, Zazulia AR (2006) Hyponatremia in neurologic patients: consequences and approaches to treatment. The Neurologist, 12:117-26.
Rabinstein AA, Mueller-Kronast N, Zazulia AR, Maramattom BV, Bamlet WR, Diringer MN, Wijdicks EFM (2006) Factors predicting prognosis after decompressive craniectomy for massive hemispheric infarction. Neurology, 67:891-3.
Zazulia AR (2006) Causes, diagnosis, and prognosis of intracerebral hemorrhage. Applied Neurology, 2:35-40
Zazulia AR (2006) Management of intracerebral hemorrhage. Applied Neurology, 2:28-33.
Zazulia AR, Videen TO, Powers WJ. (2007) Symptomatic autoregulatory failure in acute ischemic stroke. Neurology, 68:389-90.
Diringer MN, Aiyagari V, Zazulia AR, Videen TO, Powers WJ. (2007) Hyperoxia does not improve cerebral metabolic rate for oxygen measured by PET in patients with acute severe head injury. J Neurosurgery,106:526-9
Zazulia AR (2008) Hydrocephalus in ICH: what do we really know? Neurocritical Care, 8:233-4.
Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T, FAST Trial Investigators (2008) Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med, 358:2127-37.
Zazulia AR (2009) Regulation of cerebral blood flow in untreated mild-to-moderate hypertension. Am J Hypertens, 22:344.
Zazulia AR, Videen TO, Powers WJ (2009) Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage. Stroke, 40:1638-43.
Dhar R, Zazulia AR, Videen TO, Zipfel GJ, Derdeyn CP, Diringer MN (2009) Red blood cell transfusion increases cerebral oxygen delivery in anemic patients with subarachnoid hemorrhage, Stroke, 40:3039-44.
Powers WJ, Videen TO, Diringer M, Aiyagari V, Zazulia A. (2009) Autoregulation after ischaemic stroke, J Hypertens, 27:2218-22.
Powers WJ, Zazulia AR (2010) PET in cerebrovascular disease. PET Clin, 5:83-106.
Zazulia AR, Videen TO, Morris JC, Powers WJ (2010) Autoregulation of Cerebral Blood Flow to Changes in Arterial Pressure in Mild Alzheimer’s Disease. J Cerebral Blood Flow Metab, 30:1883-9.
Diringer MN, Scalfani MT, Zazulia AR, Videen TO, Dhar R (2011) Cerebral hemodynamic and metabolic effects of equi-osmolar doses mannitol and 23.4% saline in patients with edema following large ischemic stroke Neurocrit Care,14:11-7.
Foster ER, Cunnane KB, Edwards DF, Morrison TM, Ewald GA, Geltman EM, Zazulia AR (2011) Executive dysfunction and depressive symptoms are associated with reduced participation in severe congestive heart failure. Am J Occup Ther, 65:306-13.
Zazulia AR, Videen TO, Diringer, MN, Powers WJ (2011) Poor Correlation between Perihematomal MRI Hyperintensity and Brain Swelling after Intracerebral Hemorrhage. Neurocrit Care, 15:436-41 DOI 10.1007/s12028-011-9578-8.
Diringer MN, Zazulia AR, Powers WJ (2011) Does ischemia contribute to energy failure in severe TBI? Transl Stroke Res, 2:517-23.
Dhar R, Scalfani MT, Zazulia AR, Videen TO, Derdeyn CP, Diringer MN (2011) Comparison of induced hypertension, fluid bolus, and blood transfusion to augment cerebral oxygen delivery after subarachnoid hemorrhage. J Neurosurgery, 116:648-56.
Diringer MN, Scalfani MT, Zazulia AR, Videen TO, Dhar R, Powers WJ. (2012) Effect of mannitol on cerebral blood volume in patients with head injury. Neurosurgery, 70:1215-8.
Scalfani MT, Dhar R, Zazulia AR, Videen TO, Diringer MN. (2012) Effect of osmotic agents on regional cerebral blood flow in traumatic brain injury. J Crit Care, 27:526.e7-12.
Dhar R, Scalfani MT, Blackburn S, Zazulia AR, Videen T, Diringer M (2012) Relationship between angiographic vasospasm and regional hypoperfusion in aneurysmal subarachnoid hemorrhage. Stroke, 43:1788-94.
Diringer MN, Zazulia AR (2012) Hemostatic therapy should be used for acute treatment of anticoagulation-related intracerebral hemorrhage. Stroke, 43:2535-6.
Vellimana A, Kadkhodayan Y, Rich K, Cross D, Moran C, Zazulia A, Lee JM, Chicoine M, Dacey R, Derdeyn C, Zipfel G. (2013) Symptomatic patients with intraluminal carotid thrombus: outcome with a strategy of initial anticoagulation. J Neurosurg, 118:34-41.
Zazulia AR, Goldhoff P (2014) Faculty and medical student attitudes about preclinical classroom attendance. Teach Learn Med, 26:1-9.
Diringer MN, Dhar R, Scalfani M, Zazulia AR, Chicoin M, Powers WJ, Derdeyn CP. Effect of high-dose simvastatin on cerebral blood flow and static autoregulation in subarachnoid hemorrhage. Neurocrit Care, in press.
Letters to the Editor
Zazulia A (2009) Mild cognitive impairment, carotid disease, and revascularization. JAMA, 301
Diringer MN, Powers WJ, Zazulia AR, Videen TO (2009) Hyperoxia and traumatic brain injury. J Neurosurgery, 110:607-11
Zazulia AR (2002) Stroke. In: Ramachandran VS, ed. Encyclopedia of the Human Brain. San Diego: Academic Press/Elsevier Science, p.475-492.
Zazulia AR, Powers WJ (2003) Positron emission tomography in cerebrovascular disease. In: Bailey DL, Townsend DW, Valk PE, and Maisey MN, eds. Positron Emission Tomography: Principles and Practice. Surrey: Springer-Verlag London Ltd, p.375-397.
Zazulia AR, Markham J, Powers WJ (2004) Cerebral blood flow and metabolism in cerebrovascular disease. In: Mohr JP, Choi D, Grotta JC, Weir B, and Wolf A, eds. Stroke: Pathophysiology, Diagnosis, and Management, 4th edition. New York: Churchill Livingstone.
Zazulia AR, Diringer MN (2005) Non-Traumatic Intracerebral and Subarachnoid Hemorrhage. In: Fink, Abraham, Kochaneck, and Vincent, eds. Textbook of Critical Care, 5th edition. Philadelphia: Elsevier Saunders.
Ford AL, Zazulia AR (2007) Primary prevention of ischaemic stroke. European Neurological Disease 2007. London: Touch Briefings, p24-28.
Zazulia AR (2009) Regulation of cerebral blood flow in untreated mild to moderate hypertension. Am J Hypertens;22:344.
Zazulia AR Critical Care Management of Ischemic Stroke. In: Continuum Lifelong Learning in Neurology: Critical Care Neurology, 2009;12(3):68-82.
Powers WJ, Zazulia AR Therapeutic implications of hemodynamic and metabolic imaging with positron emission tomography in acute stroke. In: Kent TA, ed. Imaging Acute Stroke. Kluwer Academic Publishers. In press.
Zazulia AR, Markham J, Powers WJ (2011) Cerebral blood flow and metabolism in human cerebrovascular disease. In: Mohr JP, Moskowitz MA, Grotta JC, Weir B, and Wolf A, eds. Stroke: Pathophysiology, Diagnosis, and Management, 5th edition. New York: Churchill Livingstone.
Zazulia AR, Diringer MN Non-Traumatic Intracerebral and Subarachnoid Hemorrhage. In: Vincent, Abraham, and Kochaneck, eds. Textbook of Critical Care, 6th edition. Philadelphia: Elsevier Saunders. In press.
Zazulia AR, Diringer MN (2011) Non-Traumatic Intracerebral and Subarachnoid Hemorrhage. In: Vincent, Abraham, Moore, Kochaneck, and Fink, eds. Textbook of Critical Care, 6th edition. Philadelphia: Elsevier Saunders.
Zazulia AR, Diringer MN (2013) Acute stroke care. Critical Care, 17:301.
Zazulia AR (2014) Primary Intracerebral Hemorrhage. In Encyclopedia of Neurological Sciences, 2nd edition. Oxford: Elsevier, Inc., p734-741.
Zazulia AR (2015) Antiplatelet and anticoagulant therapy after intracerebral hemorrhage. Neurologic Clinics 33:329-45.
Dr. Zazulia is the Associate Dean for Continuing Medical Education (CME) at Washington University and is the director of Pre-clinical Neurological Education for Washington University medical students and the Department of Neurology.
In her CME role, she leads the University office dedicated to promoting life-long learning and professional development across the medical continuum and assisting health care professionals in maintaining professional competencies and performance to improve patient care.
Dr. Zazulia has been involved in pre-clinical neurological education since 2001, teaching the neurological exam to first and second year medical students, leading a selective entitled “Clinical Correlations in the Neurosciences” for first year students, and directing “Diseases of the Nervous System,” a coordinated course in neuropathophysiology, neuropathology, and neuropharmacology for second year students. She is the faculty preceptor for the Student Interest Group in Neurology (SIGN) and Camp Neuro, a non-profit summer day camp for high school students interested in exploring a career in medical neuroscience and established the College Student Interest Group in Neurology (Synapse, formerly Co-SIGN) at the undergraduate campus of Washington University. She directs an annual 16-part series entitled “Evidence-Based Management of Cerebrovascular Disease” and regularly teaches residents, clerkship medical students, and physical and occupational therapy students. She has had a prominent role in mentoring trainees and junior faculty aspiring to a research career in medicine, recently serving as the Assistant Program Director of the Clinical Research Training Center, program mentor in the Masters in Science in Clinical Investigation program, and co-director of the Neuroscience T32 Institutional Training Grant at Washington University.
On the national level, Dr. Zazulia has positions on education committees through the American Board of Psychiatry and Neurology, the National Board of Medical Examiners, the American Stroke Association, and the American Academy of Neurology. She is an elected fellow of the American Neurological Association and the American Heart Association. She is a member of the Alpha Omega Alpha Medical Honor Society, American Academy of Neurology, American Heart Association Scientific Council on Stroke, Alliance for Continuing Education in the Health Professions, and Society for Academic Continuing Medical Education.
Dr. Zazulia’s research interests are in medical education and engaging residents in process improvement. Her former research program involved use of positron emission tomography (PET) and magnetic resonance imaging (MRI) to study cerebrovascular regulation following acute intracerebral hemorrhage, ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury and to study cerebrovascular effects of Alzheimer’s disease and of severe congestive heart failure/cardiac transplantation.