Research & the R25

We are fortunate to boast one of the highest acceptance rates for trainees applying to the prestigious R25 grant. To date, 90% of applicants have had their projects funded (compared to the national average of 40-50%).

Some of our R25 awardees

Enmanuel Perez, MD, PhD

"Effect of astrocyte and microglial ApoE on TBI-mediated neuroinflammation and neurodegeneration."

Enmanuel Perez's research mentor is David Holtzman, MD, and his co-mentor is Terrance Kummer, MD, PhD. Perez will utilize novel transgenic mice, developed by the Holtzman lab, to better understand the long-term influences of glial-subtypes on neurodegenerative cascades in the injured brain and provide an opportunity to develop neuroprotective therapies.

Victoria Levasseur, MD

"Gradient echo imaging for multiple sclerosis diagnosis and central nervous system damage measurement: brain imaging in human subjects and animal models of multiple sclerosis"

Victoria Levasseur’s research mentor is Anne H. Cross, MD, and in collaboration with Dmitriy Yablonskiy, PhD, she used gradient echo plural contrast imaging (GEPCI) to study the central vein sign (CVS), a novel non-invasive biomarker for the diagnosis of MS. Utilizing a cuprizone toxin model of CNS demyelination and remyelination, she is working to determine the histopathological correlates of GEPCI quantitative metrics. She is currently a fellow in multiple sclerosis/neuroimmunology at Washington University.

Caroline Tang, MD, PhD

“Modeling microglial-retinal ganglion cell loss in NF-1 optic gliomas”

Caroline Tang joined the research laboratory of the Neurofibromatosis Center director, David H. Gutmann, MD, PhD, to study vision loss in the setting of NF-1 optic glioma, with a particular focus on modeling the interaction between microglia and the retinal ganglion cells in vitro.

Caroline has recently completed her residency and is pursuing a dual fellowship in dementia and neuro-ophthalmology.

Matthew Brier, MD, PhD

“Multimodal approach to the clinicoradiographic dissociation in multiple sclerosis”

Matt Brier’s research mentors are Anne Cross, MD, (Dept. of Neurology) and  Tammie Benzinger, MD, PhD, (Dept. of Radiology). Brier develops advanced imaging and statistical tools which rely on clinically available MRI images to improve the prediction of future disease severity and clinical disability in patients with multiple sclerosis. The goal of this work is to resolve the dissociation between what is seen on MR of the brain and spine and the clinical disability experienced by the patient. Brier is currently in Instructor of Neurology at Washington University in St. Louis within the Department of Neurology.

Other Research Opportunities

Resident Research

The Neurology Department at Washington University is committed to advancing treatment of neurological disorders through both clinical and basic science research. We believe that combining clinical service and research during residency training is the best way to develop critical thinking skills and learning habits. All full-time faculty members are actively involved in clinical or basic research and residents are encouraged to pursue their own research interests during residency, either within the Neurology Department or outside the department in other Washington University Neuroscience Laboratories.

Residents learn about the research-taking place within the department and university at regular conferences. In addition to the broad range of neuroscience research represented at Washington University, regularly scheduled lectures by visiting lecturers from other institutions provide exposure to the broader research community.

Research labs

ADRC

Hope Center

MS Center

Neurofibromatosis Center


Opportunities

Postdoctoral Research Opportunities 

Research


Resident Symposium

Residents are invited to participate in research during elective time in the second and third years of training. Many residents have co-authored publications during their residency. All residents are invited to present a poster on their research at the Residents Day Symposium held at the end of the academic year. PGY4 residents are required to present a poster. The best presentation receives the Leonard Berg Prize for resident research. These presentations range from interesting and informative case reports and case studies to clinical and basic science research studies that might form the basis for research projects during fellowship.

Resident Symposiums