Research Labs

Faculty engaged in medical research are associated with separate laboratories focused on specific conditions or illnesses. The full list of Faculty Research Interests shows those assignments, and the laboratories are described below.

Ances Laboratory

The Ances Lab is a neuroscience research lab at Washington University School of Medicine in Saint Louis that is focused on:

  1. Developing structural and functional neuroimaging biomarkers of normal aging and neurodegeneration (including Alzheimer’s Disease (AD), HIV Associated Neurocognitive Disorders (HAND), and Creutzfeld-Jacob Disease (CJD)) and
  2. Therapeutic interventions to improve neurocognitive deficits associated with neurodegenerative disorders.

Bateman Laboratory

Our laboratory’s focus is on the causes, diagnosis and future treatments of Alzheimer disease. We directly measure the pathophysiology of Alzheimer disease in humans using multiple techniques and also perform in vitro cell culture experiments.

Brody Laboratory

Research in our laboratory and collaborative group is focused on the development of novel therapeutic and diagnostic strategies for traumatic brain injury (TBI).

Cairns Laboratory

Nigel Cairns is interested in clarifying the pathological changes in the brains of these patients who come to autopsy and the mechanisms by which nerve cells die and cause dementia.

Clifford Laboratory

Dr. Clifford has a broad interest in neuropharmacology. Development of more successful medical management of neurological disease has been his clinical focus, and has included participation in studies of epilepsy, Parkinson’s disease, multiple sclerosis, and virtually all neurologic complications of HIV.

Cirrito Laboratory

Connolly Laboratory

Anne Connolly, M.D. is an expert in pediatric neuromuscular disease and neuroimmunology. She is involved in several clinical studies examining the relationship between auto-antibodies and childhood neurological disorders, including opsoclonus/myoclonus, epilepsy, autism, and peripheral nerve injury.

Corbetta Laboratory

My research aims to understand the neural basis of human cognition, in particular vision and attention. Areas of the human brain involved in these processes are visualized in vivo in normal volunteers using functional magnetic resonance imaging (fMRI).

Criswell Laboratory

Information Coming Soon

Cross Laboratory

The goal of our research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (brain and spinal cord).

Dhar Laboratory

Information Coming Soon

Diringer Laboratory

All NNICU physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a Positron Emission Tomography (PET) scanner located on site.

Dosenbach Laboratory

Plasticity is one of the hallmark features of the human brain. Use-driven plasticity is critically important for typical development as well as recovering from brain injury. Thus, the overarching goal of our research is to better understand use-driven brain plasticity.

Eisenman Laboratory

All NNICU physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a Positron Emission Tomography (PET) scanner located on site.

Fagan Laboratory

Dr. Fagan is a Washington University Alzheimer’s Disease Research Center Investigator, a faculty member of the Hope Center for Neurological Disorders, and the 2006 recipient of the Alzheimer’s Disease Neuroimaging Award (New Investigator) awarded by the Alzheimer’s Association.

Golumbek Laboratory

Information Coming Soon

Gurnett Laboratory

Dr. Gurnett has an interest in understanding the genes involved in inherited forms of epilepsy. Her current approach is to study large families with epilepsy or individuals with unusual chromosomal malformations.

Gutmann Laboratory

Our laboratory employs numerous complementary experimental platforms, including human induced pluripotent stem cells and novel genetically-engineered mouse strains, to define the molecular and cellular pathogenesis of pediatric brain tumors and cognitive dysfunction relative to improved risk stratification and treatment strategies for children affected with these nervous system problems.

Harms Laboratory

Dr. Harms’ laboratory investigates the genetic landscape of amyotrophic lateral sclerosis (ALS) and a range of other hereditary neuromuscular diseases that includes CMT, SMA, and LGMD. These efforts use next-generation sequencing technology to understand the mutational spectrum of known genes in these diseases, but focus strongly on novel gene discovery. 

Holtzman Laboratory

A major interest in my lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer’s disease (AD) and injury to the developing brain. There are two major areas of focus currently in my lab.

Hyrc Laboratory

Dr. Hyrc is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.

Jacquin Laboratory

Originally from Pomona California, Dr. Jacquin received his BA in Psychology from Brandeis University and, in 1980, his PhD in Neurobiology from the City University of New York.

Kotzbauer Laboratory

We are working to understand mechanisms of neurodegeneration underlying Parkinson’s disease and related disorders. Specific types of pathological neuronal inclusions that occur in Parkinson’s disease also occur in other neurodegenerative diseases, suggesting that common mechanisms of pathogenesis may be involved.

Lee Laboratory

Alzheimer’s Disease (AD) is associated with the accumulation of aggregated amyloid-beta peptide (Abeta) in senile plaques within the brain.

Li Laboratory

We are developing new vectors for neurological applications. The goal of the Viral Vectors Core is to assist Washington University neuroscience researchers in the design and production of various kinds of vectors.

Maccotta Lab

Dr. Maccotta’s current research studies are directed at using behavioral and functional neuroimaging techniques to help epilepsy patients overcome memory deficits, since memory is one of the most adversely affected cognitive functions in epilepsy and the most reported by patients. He also is using behavioral and functional neuroimaging techniques to find a way of making early intervention in those with a first time seizure, as well as help to identify patterns of brain functional reorganization in early epilepsy (and ideally pre-clinical epilepsy) that predict future disease severity and can be used by physicians to guide early intervention and more aggressive therapy.

MacDonald Laboratory

Miller Laboratory

The Miller Laboratory is dedicated to understanding neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and dementias, in order to develop new, effective, and safe treatments. Part of the Department of Neurology at Washington University School of Medicine in St. Louis, the Miller Laboratory is headed by Timothy M. Miller, MD, PhD, the David Clayson Professor of Neurology. Dr. Miller is a national leader in translational neuroscience and new therapeutic approaches for neurodegenerative diseases.

Morris Laboratory

The focus of Dr. Morris’ research and practice is Alzheimer’s disease and other neurological disorders associated with aging.

Musiek Laboratory

The Musiek lab studies how circadian rhythms and the circadian clock system influence neurodegenerative diseases, in particular Alzheimer’s Disease. Research focuses on the molecular mechanisms by which the circadian clock regulates processes such as inflammation, oxidative stress, and protein aggregation in cellular and animal models of Alzhiemer’s Disease and other age-related neurodegenerative conditions.

Naismith Laboratory

Information Coming Soon

Neil Laboratory

Our research group is focused on application of magnetic resonance methods to obtain a better understanding of brain injury.

Perlmutter Laboratory

Dr. Perlmutter’s main research interests include neuroimaging, basal ganglia physiology and pharmacology, mechanisms of deep brain stimulation, pathophysiology of dystonia, development of new agents to reduce nigrostriatal injury and electronic medical records systems.

Pestronk Laboratory

Information Coming Soon

Petersen Laboratory

We use behavioral and functional neuroimaging techniques to study the neural mechanisms underlying attention, language, learning and memory. Our current focus has been on aspects of experience-dependent change.

Racette Laboratory

My research interests include the genetics of Parkinson’s disease (especially in people of Amish ancestry), Welding related Parkinson’s disease, and investigations into new medications for Parkinson’s disease, dystonia, and Huntington’s disease.

Roe Laboratory

The mission of the Roe lab is to characterize the long-term impact of Alzheimer’s Disease brain pathology on cognitive functioning, driving, stress, mood, and other outcomes among persons with and without dementia symptoms.

Schlaggar Laboratory

Dr. Schlaggar’s current research efforts are directed at brain activation studies in development and plasticity of human cognition and language using functional MRI. His clinical responsibilities include pediatric movement disorders, pediatric stroke, and hemiplegic cerebral palsy. His graduate work explored the specification of neocortical areas.

Shulman Laboratory

Current studies are directed at using neuroimaging methodologies such as functional magnetic resonance imaging (fMRI) to understand visual perception and attention in healthy adults.

Snider Laboratory

My laboratory is interested in exploring how neurons die in neurodegenerative disorders and stroke, with a specific focus on how abnormally folded proteins, such as amyloid b-peptide and polyglutamine-containing proteins, cause neuronal death.

Thio Laboratory

Dr. Thio’s research interests are cellular neurophysiology, inhibitory glycine receptors, and ketogenic diet. He holds clinic weekly, is Consultant Pediatric Epileptologist for the Pediatric Cerebral Palsy Center, and serves on the Pharmaceutical, Diagnostics, and Therapeutics Subcommittee at St. Louis Children’s Hospital.

Videen Laboratory

Our laboratory studies functional activation of the brain and changes in brain physiology accompanying disease or other pathophysiology. We use PET, MRI and CT to study both human and non-human primates and have particular interests in stroke, traumatic brain injury and movement disorders.

Weihl Laboratory

Our goal is to understand the molecular mechanisms of protein inclusion formation, disaggregation and clearance in myodegenerative (skeletal muscle) and neurodegenerative diseases.

Wong Laboratory

The primary goal of my research laboratory is to understand biological mechanisms in the brain underlying epilepsy, with the ultimate purpose of developing new therapies for epilepsy patients.

Wu Laboratory

The main goal of our research is to define the antigen presentation requirements during inflammation within the central nervous system (CNS). Several different antigen presenting cells (APCs) participate in CD4 T cell-mediated immunity.

Zazulia Laboratory

Our research primarily involves using the PET scanner located in the Neurology/Neurosurgery ICU to study cerebrovascular regulation following intracerebral hemorrhage, ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury.

Zempel Laboratory

By studying a model system of partial seizures which has been adapted to the magnetic resonance environment, allowing the measurement of electrical signals concurrent with imaging. Using conventional and newly developed magnetic resonance techniques, Dr. Zempel and his colleagues have localized ongoing seizure activity and characterized the damage that occurs with seizures.