Research Labs

Faculty engaged in medical research are associated with separate laboratories focused on specific conditions or illnesses. The full list of Faculty Research Interests shows those assignments, and the laboratories are described below.

Aravamuthan Laboratory

The Aravamuthan lab’s translational research spans animal and patient-based studies to better diagnose, predict, and understand the causes of dystonia following neonatal brain injury.

Balls-Berry Laboratory

Joyce (Joy) E. Balls-Berry, PhD, is a psychiatric epidemiologist and health educator. Her primary research focuses on applying community and patient engaged research principles in diverse populations to reduce health disparities and increase health equity. Much of Balls-Berry’s research centers on determining ways to increase diversity and inclusion in clinical and translational science.

Bateman Laboratory

Our laboratory’s focus is on the causes, diagnosis and future treatments of Alzheimer disease. We directly measure the pathophysiology of Alzheimer disease in humans using multiple techniques and also perform in vitro cell culture experiments.

Clifford Laboratory

Dr. Clifford has a broad interest in neuropharmacology. Development of more successful medical management of neurological disease has been his clinical focus, and has included participation in studies of epilepsy, Parkinson’s disease, multiple sclerosis, and virtually all neurologic complications of HIV.

Cirrito Laboratory

My lab focuses on understanding the metabolism Abeta within the brain extracellular fluid, or interstitial fluid (ISF). We developed a novel in vivo microdialysis technique that enables us to specifically measure ISF Abeta within the brains of living and awake wildtype and APP transgenic mice.

Connolly Laboratory

Anne Connolly, M.D. is an expert in pediatric neuromuscular disease and neuroimmunology. She is involved in several clinical studies examining the relationship between auto-antibodies and childhood neurological disorders, including opsoclonus/myoclonus, epilepsy, autism, and peripheral nerve injury.

Corbetta Laboratory

My research aims to understand the neural basis of human cognition, in particular vision and attention. Areas of the human brain involved in these processes are visualized in vivo in normal volunteers using functional magnetic resonance imaging (fMRI).

Criswell Laboratory

Information Coming Soon

Cross Laboratory

The goal of our research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (brain and spinal cord).

Dhar Laboratory

We seek to leverage data and image-driven approaches to understand the heterogeneity of human responses to severe brain injuries.

Diringer Laboratory

All NNICU physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a Positron Emission Tomography (PET) scanner located on site.

Dosenbach Laboratory

Plasticity is one of the hallmark features of the human brain. Use-driven plasticity is critically important for typical development as well as recovering from brain injury. Thus, the overarching goal of our research is to better understand use-driven brain plasticity.

Eisenman Laboratory

All NNICU physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a Positron Emission Tomography (PET) scanner located on site.

Fluid Biomarker Core Laboratory

The Fluid Biomarker Core has studied Alzheimer Disease from multiple angles for more than 20 years. Currently the lab focuses on fluid biomarkers of disease with a particular interest in identifying individuals with preclinical and early stage AD. Our laboratory uses Enzyme Linked Immunosorbent Assays (ELISA), bead-based immunoassays, single-molecule counting systems, and automated immunoassays to study protein biomarkers in cerebrospinal fluid and plasma.

Geisler Laboratory

The goal of our lab is to identify new therapeutic agents that can be translated into relevant treatment strategies for patients suffering from peripheral neuropathies. We integrate genetic data from patients and analysis of patient-derived neurons with information from cell and animal models to gain insight into molecular mechanisms underlying axon degeneration and regeneration.

Gurnett Laboratory

Dr. Gurnett has an interest in understanding the genes involved in inherited forms of epilepsy. Her current approach is to study large families with epilepsy or individuals with unusual chromosomal malformations.

Gutmann Laboratory

Our laboratory employs numerous complementary experimental platforms, including human induced pluripotent stem cells and novel genetically-engineered mouse strains, to define the molecular and cellular pathogenesis of pediatric brain tumors and cognitive dysfunction relative to improved risk stratification and treatment strategies for children affected with these nervous system problems.

Holtzman Laboratory

A major interest in my lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer’s disease (AD).

Hyrc Laboratory

Dr. Hyrc is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.

Ju Laboratory

We study the relationship between sleep and neurodegenerative diseases through translational and clinical research.

Kotzbauer Laboratory

We are working to understand mechanisms of neurodegeneration underlying Parkinson’s disease and related disorders. Specific types of pathological neuronal inclusions that occur in Parkinson’s disease also occur in other neurodegenerative diseases, suggesting that common mechanisms of pathogenesis may be involved.

Kummer Laboratory

Research in the Kummer lab and in our collaborative group is focused on the mechanisms of cellular damage in traumatic brain injury (TBI)and in Alzheimer’s disease, with a particular focus on synaptic and other forms of gray matter injury. TBI is a major cause of morbidity and mortality in the United States and worldwide, and a major risk factor for the development of Alzheimer’s disease.

Lee Laboratory

Alzheimer’s Disease (AD) is associated with the accumulation of aggregated amyloid-beta peptide (Abeta) in senile plaques within the brain.

Li Laboratory

We are developing new vectors for neurological applications. The goal of the Viral Vectors Core is to assist Washington University neuroscience researchers in the design and production of various kinds of vectors.

Lucey Laboratory

Our lab investigates the relationship between sleep, aging, and Alzheimer’s disease. Recent evidence suggests a role for sleep in Alzheimer’s disease pathogenesis and/or as a marker for the onset and/or progression of Alzheimer’s disease that could be followed as an outcome measure in treatment trials. The major goal of our research is use sleep to prevent or delay Alzheimer’s disease.

Maccotta Laboratory

Dr. Maccotta’s current research studies are directed at using behavioral and functional neuroimaging techniques to help epilepsy patients overcome memory deficits, since memory is one of the most adversely affected cognitive functions in epilepsy and the most reported by patients. He also is using behavioral and functional neuroimaging techniques to find a way of making early intervention in those with a first time seizure, as well as help to identify patterns of brain functional reorganization in early epilepsy (and ideally pre-clinical epilepsy) that predict future disease severity and can be used by physicians to guide early intervention and more aggressive therapy.

MacDonald Laboratory

Mazzoni Laboratory

My research is based in the Movement Science Research Center in the Program in Physical Therapy at Wash U. Within this center, I am part of the Movement and Neurodegenerative Disease research group, directed by Gammon Earhart and composed of several faculty members, postdoctoral fellows, and graduate students. I also collaborate with movement scientists, engineers, and choreographers at other institutions.

Miller Laboratory

The Miller Laboratory is dedicated to understanding neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and dementias, in order to develop new, effective, and safe treatments. Part of the Department of Neurology at Washington University School of Medicine in St. Louis, the Miller Laboratory is headed by Timothy M. Miller, MD, PhD, the David Clayson Professor of Neurology. Dr. Miller is a national leader in translational neuroscience and new therapeutic approaches for neurodegenerative diseases.

Morris Laboratory

The focus of Dr. Morris’ research and practice is Alzheimer’s disease and other neurological disorders associated with aging.

Musiek Laboratory

The Musiek lab studies how circadian rhythms and the circadian clock system influence neurodegenerative diseases, in particular Alzheimer’s Disease. Research focuses on the molecular mechanisms by which the circadian clock regulates processes such as inflammation, oxidative stress, and protein aggregation in cellular and animal models of Alzhiemer’s Disease and other age-related neurodegenerative conditions.

Naismith Laboratory

Information Coming Soon

Neil Laboratory

Our research group is focused on application of magnetic resonance methods to obtain a better understanding of brain injury.

Perlmutter Laboratory

Dr. Perlmutter’s main research interests include neuroimaging, basal ganglia physiology and pharmacology, mechanisms of deep brain stimulation, pathophysiology of dystonia, development of new agents to reduce nigrostriatal injury and electronic medical records systems.

Pestronk Laboratory

Information Coming Soon

Petersen Laboratory

We use behavioral and functional neuroimaging techniques to study the neural mechanisms underlying attention, language, learning and memory. Our current focus has been on aspects of experience-dependent change.

Piccio Laboratory

The main focus of our research is to dissect inflammatory, immune-mediated and neurodegenerative mechanisms implicated in multiple sclerosis (MS) and other neurodegenerative diseases. The major goals are to identify potential new avenues for therapeutic intervention or disease prevention.

Racette Laboratory

My research interests include the genetics of Parkinson’s disease (especially in people of Amish ancestry), Welding related Parkinson’s disease, and investigations into new medications for Parkinson’s disease, dystonia, and Huntington’s disease.

Roe Laboratory

The mission of the Roe lab is to characterize the long-term impact of Alzheimer’s Disease brain pathology on cognitive functioning, driving, stress, mood, and other outcomes among persons with and without dementia symptoms.

Saligrama Laboratory

The focus of the Saligrama lab is on T Cell Repertoire in Autoimmunity, T Cell Specificity and Function in Autoimmunity and Systems Analysis of Immune System in Neurological Disorders.

Shulman Laboratory

The laboratory uses functional magnetic resonance imaging to study human attention, perception, and cognition. A second focus concerns the changes in brain organization and behavior following a stroke.

Thio Laboratory

Dr. Thio’s research interests are cellular neurophysiology, inhibitory glycine receptors, and ketogenic diet. He holds clinic weekly, is Consultant Pediatric Epileptologist for the Pediatric Cerebral Palsy Center, and serves on the Pharmaceutical, Diagnostics, and Therapeutics Subcommittee at St. Louis Children’s Hospital.

Videen Laboratory

Our laboratory studies functional activation of the brain and changes in brain physiology accompanying disease or other pathophysiology. We use PET, MRI and CT to study both human and non-human primates and have particular interests in stroke, traumatic brain injury and movement disorders.

Weihl Laboratory

Our goal is to understand the molecular mechanisms of protein inclusion formation, disaggregation and clearance in myodegenerative (skeletal muscle) and neurodegenerative diseases.

Wong Laboratory

The primary goal of my research laboratory is to understand biological mechanisms in the brain underlying epilepsy, with the ultimate purpose of developing new therapies for epilepsy patients.

Wu Laboratory

The main goal of our research is to define the antigen presentation requirements during inflammation within the central nervous system (CNS). Several different antigen presenting cells (APCs) participate in CD4 T cell-mediated immunity.

Zazulia Laboratory

Our research primarily involves using the PET scanner located in the Neurology/Neurosurgery ICU to study cerebrovascular regulation following intracerebral hemorrhage, ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury.

Zempel Laboratory

By studying a model system of partial seizures which has been adapted to the magnetic resonance environment, allowing the measurement of electrical signals concurrent with imaging. Using conventional and newly developed magnetic resonance techniques, Dr. Zempel and his colleagues have localized ongoing seizure activity and characterized the damage that occurs with seizures.