Chia-Ling Phuah, MD, MMSc

Assistant Professor of Neurology

Phone: 314-273-1456

Chia-Ling Phuah received her MD degree from the University of Cambridge (Cambridge, United Kingdom), and completed her residency in Neurology, and fellowship in Neurocritical Care with the Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical School training program. She subsequently completed a postdoctoral fellowship in stroke genetics with the Center for Human Genetics Research (MGH)/ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA. She joined the Neurocritical Care Section at Washington University School of Medicine in July 2016. Dr. Phuah’s research program is focused on understanding the pathophysiology of cerebrovascular disease by leveraging big data approaches in combining genetic, clinical, and neuroimaging data, with the overarching goal of deriving clinical relevant information to drive innovations in treatment strategies, and improve precision in clinical decision-making and risk stratification. In particular, her current efforts focus on dissecting the contribution of cerebral small vessel disease in vascular and mixed dementias using multidisciplinary and multiphenotype approaches in order to develop strategies for prevention and treatment of cognitive decline in cerebrovascular and neurodegenerative disorders.


  • 2003, Bachelor of Arts with Honours, BA Hons (Cantab): University of Cambridge, UK
  • 2005, Bachelor of Medicine & Surgery, MBBChir (Cantab): University of Cambridge, UK
  • 2016, Master of Medical Sciences, MMSc: Harvard University, Boston, MA

Board Certifications

  • Diplomate, American Board of Psychiatry and Neurology (ABPN)
  • Diplomate, United Council for Neurology Subspecialties (UCNS)
  • Neurocritical Care (NCC)


  1. Anderson CD*, Falcone G*, Phuah CL, Radmanesh F, Brouwers H, Battey T, Biffi A, et al. Genetic variants in CETP increases risk of intracerebral hemorrhage. Ann Neurol. 2016 Nov;80(5):730-740
  2. Morotti A, Charidimou A, Phuah CL, Jessel MJ, Schwab K, Ayres AM, Romero JM, Viswanathan A, Gurol ME, Greenberg SM, Anderson CD, Rosand J, Goldstein JN. Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage. JAMA Neurol. 2016 Nov 1;73(11):1285-1290
  3. Morotti A, Phuah CL, Anderson CD, Jessel M, Schwab K, Ayres A, Pezzini A, Padovani A, M. Edip Gurol, Viswanathan A, Greenberg SM, Goldstein J, and Rosand J. Leukocyte count and intracerebral hemorrhage expansion. Stroke 2016;47(6):1473-8
  4. Phuah CL, Raffeld M, Ayres A, M. Edip Gurol, Viswanathan A, Greenberg SM, Biffi A, Rosand J, Anderson CD. APOE polymorphisms influence longitudinal lipid trends preceding primary intracerebral hemorrhage. Neurology Genetics 2016:Jun 23;2(4):e81
  5. Phuah CL, Raffeld M, Ayres A, Viswanathan A, Greenberg SM, Biffi A, Rosand J, Anderson CD. Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage. Neurology 2016;86(22):2034-41
  6. Jones JL, Anderson JM, Phuah CL, Compston A, Coles AJ. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain 2010 Aug:133(Pt 8):2232-47
  7. Jones JL, Phuah CL, Cox AL, Compston A, Coles AJ. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest 2009 Jul;119(7):2052-61
  8. Javid B, Phuah CL, Lever A. A pain in the neck. J Infect. 2008;56(4):310.
  9. Phuah CL, Javid B, Aliyu S, Lever AML. A case of Mycoplasma hominis septic arthritis postpartum. J Infect. 2007 Nov;55(5):e135-7
  10. Holtzman T, Mostofi A, Phuah CL, Edgley SA. Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord J Physiol. 2006;577(1):69-80