Washington University School of Medicine

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Post Doctoral Research Opportunities

NeurofibromatosisPostdoctoral Fellowship positions are available to investigate normal growth control and tumor formation in the mammalian brain. Our laboratory is interested in understanding the key signals that control normal neural stem cell (NSC) and glial cell growth and differentiation in vitro and in vivo. To this end, we study the genes mutated in the two cancer predisposition syndromes, neurofibromatosis 1 (NF1) and neurofibromatosis 2 (NF2), in which affected individuals develop brain tumors. We have generated numerous genetically-engineered mouse models to explore the relationship between developmental neurobiology (normal growth regulation in the brain) and neuro-oncology (brain tumor formation). Ongoing projects are focused on the use of these small-animal models to (1) define the contribution of the brain microenvironment to tumor formation, (2) identify new targets for therapeutic drug design by defining the critical intracellular signaling pathways that regulate cell growth in astrocytes and neurons, and (3) understand the relationship between neural stem cells and brain tumor development. Trainees will function in a highly interactive multidisciplinary research environment focused on translating basic science discoveries to the clinical workplace (www.nfcenter.org).