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Movement Disorders Clinical Studies

Various clinical studies are currently enrolling patients with Parkinson Disease/Parkinsonism, Dystonia, Tourette Syndrome or Tics, Huntington Disease, Tremor and other types of movement disorders. If you are interested in participating in clinical studies in our division, please contact the research coordinator for each study.
Control Participants
Control subjects without movement disorders are needed for various studies. if you are interested in being a control participant in our studies, please contact the appropriate contact person noted below for eligibility.
 
Parkinson Disease

A Phase 3 double-blind placebo-controlled parallel group study of isradipine as a disease modifying agent in subjects with early Parkinson disease (STEADY-PD III Study) (more details)

Brad Racette, MD

Karen McDonell

314-747-0514

Exercise and Parkinson's: Comparing Interventions and Exploring Neural Mechanisms (more details)

 

Gammon Earhart, PT, PhD

Martha Hessler

314-286-1478

Efficacy and Safety of ADS-5102 (amantadine HCl) Extended Release Capsules for the Treatment of Levodopa Induced Dyskinesia in Parkinson’s Disease Patients (EASE LID Study). (more details)

Susan Criswell

Karen McDonell 314-747-0514

Feasibility and Optimization of a Cognitive Intervention for Parkinson disease. (more details)

Erin Foster

Tasha Doty

314-362-7160

A Phase 3, 12-week, Double-Blind, Placebo-Controlled, Randomized, Multicenter Study to Evaluate the Effficacy of Oral Istradefylline 20 and 40 mg/day as Treatment for Subjects with Moderate to Severe Parkinson's Disease.(more details)

Susan Criswell, MD

Karen McDonell

314-747-0514

Chronic Disease Self-Management for Parkinson Disease (CDSM4PD) (more details)

Erin Foster

Tasha Doty

314-362-7160

Use of PIB PET imaging to evaluate dementia subtypes in patients with Parkinson Disease
(more details)
Joel Perlmutter Johanna Hartlein
314-362-6026
Mapping Mood in the Subthalamic Nucleus in PD (more details) Tamara Hershey Samantha Blankenship
314-362-6514
Effects of Dopamine on Functional Connectivity in Parkinson Disease (more details) Joel Perlmutter Johanna Hartlein
314-362-6026
Molecular Genetic Studies of Parkinsonism (more details) Joel Perlmutter

Stacy Pratt
314-747-5916

Huntington's Disease
Study Title Principal Investigator Contact
Neurobiological Predictors of Huntington Disease, Version 2.0 (PREDICT-HD v 2.0) (more details) (study brochure) Joel Perlmutter

Stacey Barton
314-362-3471

Creatine Safety, Tolerability & Efficacy in huntington's Disease. (more details) Brad Racette Pat Deppen
362-8548
Dystonia
Study Title Principal Investigator Contact
Dystonia Coalition: Project 1: Natural History and Biorepository for Primary Dystonia. (Study Brochure) Joel Perlmutter

Laura Wright

362-7148

Role of Dopamine Receptors in Primary Focal Dystonias (more details) Morvarid Karimi

Stacy Pratt

314-747-5916

Tourette Syndrome or Tics
Study Title Principal Investigator Contact

Testing the phasic dopamine release hypothesis in Tourette syndrome: pilot

Kevin Black

Emily Bihun (314) 362-2083; bihune@npg.wustl.edu

The effects of tactile stimulation on the attentional performance of subjects with sensory hypersensitivity or Tourette syndrome: pilot

Kevin Black

Jackie Schechter, email: volunteer@tourette.us

Predictive Biomarkers of Conversion to Tourette Syndrome in Children with New-Onset Tics (more details) Kevin Black

Emily Bihun (314-362-2083) BihunE@npg.wustl.edu

Others
Study Title Principal Investigator Contact
Allergan Post Stroke Upper Limb Spasticity.   (more details) (flyer) Brad Racette, MD

Laura Rundell

314-362-3372

Myobloc for Sialorrhea Treatment with Intraglandular Injections – Controlled and Open-Label Study. (more details) Brad Racette, MD

Karen McDonell

314-747-514

Biospecimen and Clinical Data Acquisition Neurological and Psychiatric Genetics Repository (more details) Joel Perlmutter

Stacy Pratt

314-747-5916