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Movement Disorders Clinical Studies

Various clinical studies are currently enrolling patients with Parkinson Disease/Parkinsonism, Dystonia, Tourette Syndrome or Tics, Huntington Disease, Tremor and other types of movement disorders. If you are interested in participating in clinical studies in our division, please contact the research coordinator for each study.
Control Participants
Control subjects without movement disorders are needed for various studies. if you are interested in being a control participant in our studies, please contact the appropriate contact person noted below for eligibility.
 
Parkinson Disease
Study Title Principal Investigator Contact
Oculomotor Control and Gait in Parkinson Disease. (more details) Gammon Earhart

John Michael Rotello
314-362-0420

Use of PIB PET imaging to evaluate dementia subtypes in patients with Parkinson Disease
(more details)
Joel Perlmutter Johanna Hartlein
314-362-6026
A double-blind, randomized, placebo-controlled study of the safety and efficacy of SYN115 as adjunctive therapy in levodopa-treated Parkinson’s subjects with end of dose wearing off. (more details) Susan Criswell Mary Pecoraro 314-747-7017
Understanding everyday cognitive functioning in Parkinson disease without dementia.(more details) Erin Foster Emily Bihun 362-2083
Mapping Mood in the Subthalamic Nucleus in PD (more details) Tamara Hershey Samantha Blankenship
314-362-6514
Effects of Dopamine on Functional Connectivity in Parkinson Disease (more details) Joel Perlmutter Johanna Hartlein
314-362-6026
Multi-Center, Placebo-Controlled, Double-Blind Trial to Examine the Safety and Efficacy of Pimavanserin the Treatment of Psychosis in Parkinson's Disease. (more details) Kevin Black Mary Creech 314-362-7651
Molecular Genetic Studies of Parkinsonism (more details) Joel Perlmutter

Stacy Pratt
314-747-5916

Rehabilitation of everyday memory impairment in Parkinson disease: A Pilot Study (more details) Erin Foster Tasha Doty
314-362-7160
A Multi-Center, Double-Blind, Placebo-Controlled Phase II Study of Pioglitazone in Early Parkinson's Disease (FS-Zone) (more details) Brad Racette Melissa Ammel
314-747-3470
Huntington's Disease
Study Title Principal Investigator Contact
Neurobiological Predictors of Huntington Disease, Version 2.0 (PREDICT-HD v 2.0) (more details) (study brochure) Joel Perlmutter Stacey Barton
314-362-3471
Creatine Safety, Tolerability & Efficacy in huntington's Disease. (more details) Brad Racette Pat Deppen
362-8548
Dystonia
Study Title Principal Investigator Contact
Dystonia Coalition: Project 1: Natural History and Biorepository for Primary Dystonia. (Study Brochure) Joel Perlmutter Ling Yan 362-7148
Dystonia Coalition: Project 2: Comprehensive Rating Tools for Cervical Dystonia. (Study Brochure) Joel Perlmutter Ling Yan 362-7148
Dystonia Coalition: Project 3: Validity and Reliability of Diagnostic Methods and Measures of Spasmodic Dysphonia. (Study Brochure) Joel Perlmutter Ling Yan 362-7148
Role of Dopamine Receptors in Primary Focal Dystonias (more details) Morvarid Karimi Stacy Pratt 314-747-5916
Tourette Syndrome or Tics
Study Title Principal Investigator Contact
Predictive Biomarkers of Conversion to Tourette Syndrome in Children with New-Onset Tics (more details) Kevin Black Mary Creech (314-362-7651) maryc@npg.wustl.edu
Tourette Syndrome Neuroimaging Consortium Pilot. (more details) Kevin Black,
Bradley Schlaggar
Mary Creech (314-362-7651) maryc@npg.wustl.edu
Others
Study Title Principal Investigator Contact
Biospecimen and Clinical Data Acquisition Neurological and Psychiatric Genetics Repository (more details) Joel Perlmutter Stacy Pratt (314-747-5916) pratts@npg.wustl.edu
Prospective, double-blind, placebo-controlled, randomized, multi-center study with an open-label extension period to investigate the efficacy and safety of NT 201 in the treatment of post-stroke spasticity of the lower limb (more details) Susan Criswell Karen McDonell (314-747-0514)
mcdonellk@neuro.wustl.edu