John C. Morris, MD
John C. Morris is the Harvey A. and Dorismae Hacker Friedman Distinguished Professor of Neurology, Professor of Pathology and Immunology, Professor of Physical Therapy, and Professor of Occupational Therapy at Washington University. He also is the Director and Principal Investigator of the Charles F. and Joanne Knight Alzheimer's Disease Research Center.
Dr. Morris is the Principal Investigator for four multicomponent research grants, awarded by the National Institute on Aging (NIA), to study various aspects of Alzheimer disease. These grants include the Knight Alzheimer Disease Research Center, which Dr. Morris directs, two program projects, “Healthy Aging and Senile Dementia” and “Antecedent Biomarkers for AD: The Adult Children Study”; and a cooperative agreement that establishes an international consortium of leading academic centers, “The Dominantly Inherited Alzheimer Network” (DIAN). Dr. Morris directs all of these programs with the overarching goal of identifying Alzheimer disease in its earliest stages, prior to the onset of any symptoms, so that therapies can be initiated to prevent the occurrence of Alzheimer dementia.
Dr. Morris is author and co-author of over 400 peer-reviewed journal articles and 60 chapters and reviews. He edited the first and second editions of the Handbook of Dementing Illnesses. He has received many honors, including the Distinguished Achievement Citation from his alma mater, Ohio Wesleyan University (2000), the Lifetime Achievement Award from the Alzheimer's Association (2004), the MetLife Foundation Award for Medical Research in Alzheimer Disease (2004), the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Disease from the American Academy of Neurology (2005), the Carl and Gerti Cori Faculty Achievement Award from Washington University (2010), the 2013 Peter H. Raven Lifetime Achievement Award from the Academy of Science St. Louis, and the Washington University School of Medicine 2013 Second Century Award He is also a board member for the St. Louis Chapter of the Alzheimer Association.
In clinical practice, Dr. Morris was recognized by his peers with the Neville Grant Award for Clinical Excellence from the Barnes-Jewish Hospital Foundation in St. Louis (2006). He received the Washington University Academic Women’s Network Mentor Award (2008). For his community service and efforts to address health care disparities and to support diversity in Alzheimer research, he was named a “Zealot” of the Monsanto Family YMCA (St. Louis) in 2005.
He is a past member of the National Advisory Council for Aging (NIA) and of the Board of Directors of the Alzheimer’s Association. He currently chairs the Clinical Task Force for the NIA’s Alzheimer’s Disease Center. He also is on the Board of Directors for the American Academy of Neurology.
Memory Disorders and Diagnosis
Patients seen at:
Memory Diagnostic Center
4488 Forest Park Avenue
St. Louis, MO 63108
Fax: (314) 286-1985
Areas of Clinical Interest
Healthy aging and Alzheimer dementia, antecedent biomarkers for Alzheimer’s disease in nondemented elderly to evaluate risk for Alzheimer dementia, and trials of investigational drugs for the treatment of Alzheimer dementia.
Dr. Morris received his B.A. from Ohio Wesleyan University. After receiving his MD from the University of Rochester School of Medicine and Dentistry in Rochester, NY, in 1974, he completed his internship at San Francisco General Hospital before joining a private practice as a family physician in Fairbanks, Alaska (1975-76) and then as an Emergency Room physician at Carlsbad Regional Medical Center in New Mexico (1976-77). Dr. Morris received board certification in Internal Medicine and Neurology after returning to Ohio to complete residency programs in medicine (Akron General Medical Center) and neurology (Cleveland Metropolitan General Hospital). He joined Washington University School of Medicine in 1982 as a postdoctoral fellow in neuropharmacology and was appointed to the faculty as an Instructor in Neurology in 1983. Dr. Morris was named as the Harvey A. and Dorismae Hacker Friedman Professor of Neurology in 1998 and Distinguished Professor in 2003.
Honors and Awards
Listed in Best Doctors in America, 2002-present (Best Doctors, Inc.)
MetLife Award for Medical Research in Alzheimer’s Disease (2004);
Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Dementias from the American Academy of Neurology (2005);
Physician-Scientist Lifetime Achievement Award, Barnes-Jewish Hospital Foundation, St. Louis, MO (2005);
Neville Grant Award for Clinical Excellence from Barnes-Jewish Hospital, St. Louis, MO (2006);
Carl and Gerty Cori Faculty Achievement Award, Washington University (2010).
2013 Peter H. Raven Lifetime Achievement Award from the Academy of Science of St. Louis;
Washington University School of Medicine 2013 Second Century Award;
2013 Medical & Scientific Honoree from the Alzheimer’s Association.
Ryman DC, Acosta-Baena N, Aisen PS, Bird TD, Danek A, Fox N, Goate AM, Frommelt P, Ghetti B, Langbaum J, Lopera F, Martin R, Masters C, Mayeux R, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Tariot PN, Xiong C, Morris JC, Bateman R, and the Dominantly Inherited Alzheimer Network. Symptom onset in autosomal dominant Alzheimer disease:A systematic review and meta-analysis. Neurology. 2014; 83:253-260
Monsell SE, Mock C, Hassenstab J, Roe CM, Cairns NJ,Morris JC, Kukull W. Neuropsychological changes in asymptomatic persons with Alzheimer’s disease neuropathology. Neurology 2014; 83:434-440..
Fagan AM, Xiong C, Jasielec M, Bateman RJ, Goate AM, Benzinger TLS, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR,Sperling R, Marcus D, Cairns NJ, Buckles VD, Ladenson JH,Morris JC, Holtzman DM, and the Dominantly Inherited Alzheimer Network. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer disease. Sci Transl Med 2014; 6:226ra30. PMCID:PMC4038930.
Morris JC, Roe CM, Xiong C, Fagan AM, Goate Am, Holtzman DM, Mintun MA. APOEPredicts Aβ but not tau Alzheimer’s pathology in cognitively normal aging. Ann Neurology 2010; 67:122-131. PMCID: PMC2830375
Morris JC, Roe CM, Xiong C, Fagan AM, Goate Am, Holtzman DM, Mintun MA. APOE Predicts Aβ but n Bateman R, Xiong C, Benzinger T, Fagan A, Goate A, Fox N, Marcus D, Cairns N, Xie X, Blazey T, Holtzman D, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk W, McDade E, Martins R, Masters C, Mayeux R, Ringman J, Rossor M, Schofield P, Sperling R, Salloway S,Morris J, for the Dominantly Inherited Alzheimer Network. Clinical and Biomarker changes in Dominantly Inherited Alzheimer’s Disease. N Engl J Med 2012; 367:795-804. PMCID: PMC3474597
Morris JC. Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia. Archives of Neurology 2012;69:700-708. . PMCID: PMC3423496
Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, Sutphen CL, Benzinger TLS, Mintun MA, Holtzman DM,Morris JC. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 2013;80:1784-1791. (PMC Journal – In Process)
Vos SJB, Xiong C, Visser PJ, Jasielee MS, Grant EA, Cairns NJ,Morris JC, Holtzman DM, Fagan AM.
Preclinical Alzheimer’s disease and its outcome: a longitudinal cohort study. Lancet Neurology 2013;12:957-965. NIHMS:NIHMSID 525894
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