Washington University School of Medicine

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Liu-Lin Thio, MD, PhD

Dr. Thio is the Director of the Pediatric Epilepsy Center.

Dr. Thio's research interests are cellular neurophysiology, inhibitory glycine receptors, and ketogenic diet. He holds clinic weekly, is Consultant Pediatric Epileptologist for the Pediatric Cerebral Palsy Center, and serves on the Pharmaceutical, Diagnostics, and Therapeutics Subcommittee at St. Louis Children's Hospital.

Medical Training

After receiving a B.S. magna cum laude in biochemistry from Brown University in Providence, Rhode Island in 1984, Dr. Thio entered the Medical Scientist Training Program at Washington University School of Medicine. He earned his combined M.D.,Ph.D. degrees in 1992. After a pediatric residency at St. Louis Children's Hospital, Dr. Thio continued his training at St. Louis Children's Hospital when he entered the child neurology residency program. He began a fellowship in pediatric epilepsy under the supervision of Dr. Blaise Bourgeois, completing his training at Harvard Medical School. He was appointed to the faculty of the Department of Neurology upon his return to Washington University School of Medicine in 1999.

Selected Publications

Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory synaptic transmission. Neurology 2000; 54: 325-331.

Thio LL, Shanmugam A, Isenberg K, Yamada K. Benzodiazepines block a2-containing inhibitory glycine receptors in embryonic mouse hippocampal neurons. Journal of Neurophysiology 2003; 90: 89-99.

Karkar KM, Thio LL, Yamada K. Effects of seven clinically important antiepileptic drugs on inhibitory glycine receptor currents in hippocampal neurons. Epilepsy Research 2004; 58: 27-35.

4. Thio LL, Yamada KA. Differential presynaptic modulation of excitatory and inhibitory autaptic currents in cultured hippocampal neurons. Brain Research 2004; 1012: 22-28.

Izumi Y, Ishikawa M, Benz AM, Izumi M, Zorumski CF, Thio LL. Acute vigabatrin retinotoxicity depends on light but not GABA. Epilepsia 2004; 45: 1043-1048.

Thio LL, Rho JM, Stafstrom CE. The ketogenic diet. Pediatric Update 2009; 29.

Thio LL, Dodson WE. Epilepsy in infancy - answering the call. Neurology 2010, In press.