Dr. Lopate is involved in both clinical and basic science studies of neuromuscular disease and also sees patients in the Neuromuscular Disease clinic and in the Electrodiagnostic Lab. Clinical research interests include participation as an investigator in drug and natural history trials for patients with ALS, autoimmune neuropathy, inflammatory myopathies and hereditary myopathies. Basic science interests focus on the role of autoantibodies in peripheral neuropathies. In particular Dr. Lopate is studying glycolipids and glycoproteins as potential targets in autoimmune disease and their role in the pathogenesis of autoimmune peripheral neuropathies.

Medical Training

Dr. Lopate was born in Cleveland, Ohio in 1961. He graduated from high school in 1979 before going to Colorado State University to obtain his Bachelor of Science degree in Zoology, graduating cum laude and being selected to join the Phi Beta Kappa society. After graduation in 1983, he went to the Ohio State University to study medicine. He graduated from medical school in 1987 and did a one-year internship at Riverside Methodist Hospital in Columbus, Ohio. He came to Barnes Hospital for neurology training in 1988, and has stayed on at Washington University after completing his residency in 1991. Dr. Lopate completed a three-year fellowship in Neuromuscular Diseases in 1994 and then became an Instructor in Neurology. He was promoted to Assistant Professor in 1999 and to Associate Professor in 2004. He is also the Chief of Neurology at St. Louis ConnectCare. He is board certified in Psychiatry and Neurology as well as in Electrodiagnostic Medicine. He is a member of the American Academy of Neurology and the American Association of Electrodiagnostic Medicine.

Selected Publications

Lopate G, Kornberg AJ, Yue J, Choksi R, Pestronk A. Anti-myelin associated glycoprotein antibodies: variability in patterns of IgM binding to peripheral nerve. J Neurol Sci 2001;188:67-72.

Lopate G, Choksi R, Pestronk A. Severe sensory ataxia and demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1a antibodies. Muscle Nerve 2002;25:828-836.

Miller T, Al-Lozi MT, Lopate G, Pestronk A. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol, Neurosurg Psychiatry 2002;73:420-428.

Pestronk A, Florence J, Levine T, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M. Sensory exam with a quantitative tuning fork: rapid, sensitive and predictive of SNAP amplitude. Neurology 2004;62:461-464.

Lopate G, Pestronk A, Al-Lozi M. Treatment of Chronic Inflammatory Demyelinating Polyneuropathy With High-Dose Intermittent Intravenous Methylprednisolone. Arch Neurol 2005;62:249-254.