Dr. Hogan is the Director of the Adult Epilepsy Center.

Dr. Hogan has research interests in multiple areas of clinical neurology, including the pharmacology and clinical use of antiepileptic medications, semiology of epileptic seizures, and neuro-imaging changes in patients with epileptic seizures.

Dr. Hogan has extensive experience as an investigator in multi-center studies of new medications for patients with refractory epileptic seizures, and has participated in studies of pharmacokinetics and clinical effects of antiepileptic medications.

Interests in semiology (interpretation of signs and symptoms) of epileptic seizures include clinical changes, such as changes in consciousness, during and after seizures. Neuro-imaging interests incorporate use of magnetic resonance imaging (MRI) and application of analytical techniques such as computational anatomy and general pattern theory to outline brain structures, such as the hippocampus. Important potential clinical applications for MRI studies include measurements of neuroanatomical brain changes to assist in diagnosis of different types of epilepsy, and to more precisely document disease progression in patients with chronic epilepsy. Research in neuro-imaging also involves single photon emission computed tomography (SPECT), which allows measurement of brain cerebral blood flow perfusion during seizures, which correlates well with the electrographic pattern of epileptic seizures. For SPECT scanning, computer-aided methods of post-image acquisition processing of ictal and interictal SPECT images, including subtraction ictal SPECT and subtraction ictal SPECT co-registered to MRI (SISCOM) can improve the clinical usefulness of SPECT, and assist in localizing seizures. Goals of his research interests in clinical semiology and neuro-imaging are to improve understanding of epileptic seizures for applications of advanced treatments for seizures, including the surgical treatment of epileptic seizures, which are refractory to traditional treatments such as medications.

Medical Training

Dr. Hogan was born in West Plains, MO, and grew up in Springfield, MO. His undergraduate education was at Augustana College in Sioux Falls, SD, where he majored in chemistry. He went to medical school at the University Missouri-Columbia. Post graduate training included an internship at Cleveland Metropolitan General Hospital, neurology residency at Case Western Reserve University, and a fellowship in epilepsy through an exchange curriculum involving Case Western Reserve University and The Royal Melbourne Hospital in Melbourne, Australia. He is board certified in neurology through the American Board of Psychiatry and Neurology, and in epilepsy monitoring through the American Board of Clinical Neurophysiology. He worked at Saint Louis University as Director of The Greater Midwest Epilepsy Treatment Center before moving to Washington University in St. Louis in 2006.

Selected Publications

Bouilleret V, Hogan RE, Velakoulis D, Salzberg M, Wang L, Egan G, O'Brien TJ, Jones NC. Morphometric abnormalities and hyperanxiety in genetically epileptic rats: a model of psychiatric comorbidity? Neuroimage. 2009; 45:267-274.

Hogan RE, Bouilleret V, Liu YR, Wang L, Williams JP, Jupp B, Myers D, O'Brien TJ. MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique. Journal of Magnetic Resonance Imaging. 2009;29:1027-1034.

Hogan RE, Carne RP, Kilpatrick CJ, Cook MJ, Patel A, King L, O'Brien TJ. Hippocampal deformation mapping in MRI-negative PET-positive temporal lobe epilepsy. Journal of Neurology Neurosurgery and Psychiatry. 2008;79:636-640.

Hogan RE, Wang L, Bertrand ME, Willmore LJ, Bucholz RD, Nassief AS, Csernansky JG. Predictive value of hippocampal MR imaging -based high-dimensional mapping in mesail termporal epilepsy: Preliminary Findings. American Journal of Neuroradiology (AJNR) 2006; 27:2149-2154

Hogan RE, Rao VK. Hemi-facial motor and crying seizures of temporal lobe onset: case report and review of electro-clinical localisation. Journal of Neurology Neurosurgery and Psychiatry 2006; 77:107-110

Hogan RE, Kaiboriboon K, Bertrand ME, Rao V, Acharya J. Composite SISCOM perfusion patterns in right and left temporal seizures. Archives of Neurology 2006; 63:1419-1426

Kaiboriboon K, Bertrand ME, Osman M, Hogan RE. Quantitative analysis of cerebral blood flow patterns in mesial temporal lobe epilepsy using composite SISCOM. Journal of Nuclear Medicine 2005; 46:38-43

Gardner R, Hogan RE. Three-dimensional deformation-based hippocampal surface anatomy, projected on MRI images. Clinical Anatomy 2005; 18:481-487

Hogan RE, Wang L, Bertrand ME, Willmore LJ, Bucholz RD, Nassif SA, Csernansky JG. MRI-based high dimensional hippocampal mapping in mesial temporal lobe epilepsy. Brain. 2004; 127:1731-1740