Washington University School of Medicine

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Nupur Ghoshal, MD, PhD

Dr. Ghoshal's research has focused on mechanisms underlying neurodegenerative disorders beginning with the tau protein in Alzheimer's disease and more recently with the progranulin protein in frontotemporal dementia. She has had the opportunity to present her work at the American Academy of Neurology (AAN), International Conference on Alzheimer's Disease (ICAD), and Society for Neuroscience (SFN) meetings. During residency she was the Chief Resident of Neurology and was inducted into AOA, the medical honor society. During fellowship, she received the Poletsky Award and the Kopolow Award both for dementia care and research.

Medical Training

Dr. Nupur Ghoshal is an Instructor in the Department of Neurology, in the Division of Aging at Washington University School of Medicine. She is also a clinical investigator in the Alzheimer's Disease Research Center (ADRC) and a physician at the Memory Diagnostic Clinic. She earned her undergraduate degree from Iowa State University, MD and PhD degrees from Northwestern University, and completed a residency in Neurology at Washington University and Barnes Jewish Hospital. She recently completed a dementia fellowship at Washington University (ADRC).

Selected Publications

Articles in press

  1. Roe, C.M., A.M. Fagan, M.M. Williams, N. Ghoshal, M. Aeschleman, E.A. Grant, D.S. Marcus, D.M. Holtzman, M.A. Mintun, and J.C. Morris, Improving CSF Biomarker Accuracy in Predicting Prevalent and Incident Alzheimer's Disease. Neurology, In press. PMC Journal - In Process.

Articles in print

  1. Ghoshal, N., Proteinase inhibitor II increases electrical activity in transgenic tobacco and poplar: method development. 6th Annual National Conference on Undergraduate Research (NCUR), 1992. 3: p. 1565-1570.

  2. Ghoshal, N., J.F. Smiley, A.J. DeMaggio, M.F. Hoekstra, E.J. Cochran, L.I. Binder, and J. Kuret, A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. Am J Pathol, 1999. 155(4): p. 1163-72. PMC1867028.

  3. Abraha, A., N. Ghoshal, T.C. Gamblin, V. Cryns, R.W. Berry, J. Kuret, and L.I. Binder, C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci, 2000. 113 Pt 21: p. 3737-45.

  4. Schwab, C., A.J. DeMaggio, N. Ghoshal, L.I. Binder, J. Kuret, and P.L. McGeer, Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiol Aging, 2000. 21(4): p. 503-10.

  5. Berry, R.W., B. Quinn, N. Johnson, E.J. Cochran, N. Ghoshal, and L.I. Binder, Pathological glial tau accumulations in neurodegenerative disease: review and case report. Neurochem Int, 2001. 39(5-6): p. 469-479.

  6. Dawson, H.N., A. Ferreira, M.V. Eyster, N. Ghoshal, L.I. Binder, and M.P. Vitek, Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci, 2001. 114(Pt 6): p. 1179-87.

  7. Ghoshal, N., F. Garcia-Sierra, Y. Fu, L.A. Beckett, E.J. Mufson, J. Kuret, R.W. Berry, and L.I. Binder, Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem, 2001. 77(5): p. 1372-85.

  8. King, M.E., N. Ghoshal, J.S. Wall, L.I. Binder, and H. Ksiezak-Reding, Structural analysis of Pick's disease derived and in vitro-assembled tau filaments. Am J Pathol, 2001. 158(4): p. 1481-90. PMC1891891.

  9. Ghoshal, N., F. García-Sierra, J. Wuu, S. Leurgans, D.A. Bennett, R.W. Berry, and L.I. Binder, Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease. Exp Neurology, 2002. 177(2): p. 475-93.

  10. García-Sierra, F., N. Ghoshal, B. Quinn, R.W. Berry, and L.I. Binder, Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease. J Alzheimers Dis, 2003. 5(2): p. 65-77.

  11. Ghoshal, N., I. Cali, R.J. Perrin, S.A. Josephson, N. Sun, P. Gambetti, and J.C. Morris, Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype. Arch Neurol, 2009. 66(10): p. 1240-6. PMC2796207.

  12. Cairns, N.J. and N. Ghoshal, FUS: A New Actor on the Frontotemporal Lobar Degeneration. Neurology, 2010. 74(5): p. 354-6.

  13. Roe, C.M., M.A. Mintun, N. Ghoshal, M.M. Williams, E.A. Grant, D. Marcus, and J.C. Morris, Enhanced Identification of Alzheimer's Disease using Amyloid Imaging: Proof of Concept. Neurology, 2010. 75(1): p. 42-48. PMC2906402.

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