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Catherine Roe, PhD

Dr. Roe is a Research Assistant Professor at the Knight Alzheimer's Disease Research Center (ADRC) within the Department of Neurology. She provides consultation and collaboration on study design, statistical analysis, and manuscript preparation to ADRC faculty and staff to address diverse research questions about clinical aspects of Alzheimer's disease. Dr Roe's research focus is on determining how the phenotypes of symptomatic and preclinical Alzheimer's disease (AD) relate to the biological and environmental factors underlying the disease mechanisms. She is especially interested in how brain and cognitive reserve factors influence preclinical and symptomatic Alzheimer's disease, in associations between Alzheimer's disease and cancer, and in the use of secondary data analysis of preexisting databases to address novel questions about Alzheimer's disease.

Medical Training

Dr. Roe earned her undergraduate degree at Purdue University, majoring in Psychology and minoring in Mathematics. She earned her MA and PhD at Southern Illinois University in Carbondale, specializing in Clinical Psychology and Experimental Psychology with an emphasis on Learning, Memory and Cognition. At Washington University, Dr. Roe completed the postdoctoral program of the Clinical Research Training Center.

Selected Publications

Peer Reviewed Publications since 2008

1. Roe CM, Xiong C, Grant E, Miller JP, Morris JC. Education and reported onset of symptoms among individuals with Alzheimer's disease. Archives of Neurology 2008;65:108-111.

2. Roe CM, Xiong C, Miller JP, Cairns NJ, Morris JC. Interaction of neuritic plaques and education predicts dementia. Alzheimer Disease and Associated Disorders 2008;22:188-193.

3. Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant E, Morris JC. Alzheimer's and cognitive reserve: variation of education effect with carbon 11-labled Pittsburgh Compound B. Archives of Neurology 2008;65:1467-1471.

4. Snider BJ, Fagan AM, Roe C, Shah AR, Grant EA, Xiong C, Morris JC, Holtzman DM. CSF biomarkers predict rate of cognitive decline in very mild dementia of the Alzheimer's type. Archives of Neurology 2009;66:638-645.

5. Williams MM, Roe CM, Morris JC. Stability of the Clinical Dementia Rating: 1979-2007. Archives of Neurology 2009;66:773-777.

6. Price JL, McKeel Jr DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen PC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 2009;30:1026-1036.

7. Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. PIB Imaging Predicts Progression to Symptomatic Alzheimer's Disease. Arch Neurol 2009;66:1469-1475.

8. Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition: implications for future clinical trials of Alzheimer's disease. EMBO Molecular Medicine 2009;1:371-380.

9. Harper P, Roe CM. Thyroid disease medication and subsequent development of dementia of the Alzheimer type. J Geriatr Psychiatry Neurol 2010;23:63-69.

10. Wilkins CH, Roe CM, Morris JC. A brief clinical tool to assess physical function in mild dementia: the Mini-PPT. Archives of Gerontology and Geriatriatrics 2010;50:96-100.

11. Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, Williams MM, Kopan R, Behrens MI, Morris JC. Cancer linked to Alzheimer's disease but not vascular dementia. Neurology 2010;74:106-112.

12. Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE genotype predicts Aβ but not tau pathology in cognitively normal aging: amyloid imaging and CSF biomarkers in preclinical Alzheimer's disease. Annals of Neurology 2010;67:122-131.
13. Palmer JL, Coats M, Roe CM, Xiong C, Hanko SM, Morris JC. Advance Practice Nurse and Neurologist Agreement on the United Parkinson's Disease Rating Scale and Physical/ Neurological Exam. Journal of Advanced Nursing 2010;66:1382-1387.

14. Dreyfus DM, Roe CM, Morris JC. Autobiographical memory task in assessing dementia. Arch Neurol 2010;67:862-866.

15. Behrens MI, Roe CM, Quest FG, Morris JC. Is there a link between dementia and cancer? Aging Health 2010;6:361-364.

16. Roe CM, Mintun MA, Ghoshal N, Williams MM, Grant EA, Marcus DS, Morris JC. Enhanced identification of Alzheimer's disease using amyloid imaging: proof of concept. Neurology 2010;75:42-48.

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